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Concurrent environmental exposures and puberty in girls.

Hormonally active environmental agents may alter the course of pubertal development in girls, which is controlled by endogenous steroids and gonadotropins. Wolff et al. (p. 1039) investigated associations of concurrent exposures from three chemical classes--phenols, phthalates, and phytoestrogens--with pubertal stages in a multiethnic longitudinal study of 1,151 girls from three regions of the United States; participants were 6-8 years of age at enrollment. The authors measured exposure biomarkers in urine samples at the first visit, and they examined associations with breast and pubic hair development 1 year later. Modification of biomarker associations by age-specific body mass index percentile (BMI%) was also investigated. High-molecular-weight phthalate (MWP) metabolites were weakly associated with pubic hair development. The authors observed small inverse associations between daidzein and breast stage, and for triclosan and high MWP with pubic hair development. They reported a positive trend for low-molecular-weight phthalate biomarkers with breast and pubic hair development. Enterolactone attenuated BMI associations with breast development. The authors conclude that weak hormonally active xenobiotic agents had small associations with pubertal development, mainly among those agents detected at the highest concentrations.

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Title Annotation:CHILDREN'S HEALTH
Publication:Environmental Health Perspectives
Article Type:Brief article
Geographic Code:1USA
Date:Jul 1, 2010
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