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Concentric Analgesics Begins Clinical Trial of CA-008 for Post-Surgical Pain Following Bunionectomy.

M2 PHARMA-November 3, 2017-Concentric Analgesics Begins Clinical Trial of CA-008 for Post-Surgical Pain Following Bunionectomy


- US-based clinical-stage biopharmaceutical company Concentric Analgesics, Inc. has initiated a Phase 1b clinical trial with CA-008, a proprietary, water-soluble prodrug that converts into capsaicin, a potent TRPV-1 agonist, the company said.

Capsaicin, which has a long history of use as a topical analgesic, selectively and reversibly desensitizes pain-conducting nerve fibers (C-fiber nociceptors).

The Phase 1b study is a randomized, double-blind clinical trial, targeting approximately 32 patients undergoing bunionectomy. The goal of the single, ascending-dose trial is to examine the safety, tolerability, and pharmacokinetics of CA-008.

In addition to the company's post-surgical program, Concentric expects to complete a series of pre-clinical research studies by the end of 2017 for CA-011, its program in osteoarthritis.

Concentric Analgesic's lead investigational product candidates, CA-008 and CA-011, convert into capsaicin, a potent TRPV-1 agonist that evokes an initial neuronal excitation that is followed by a durable refractory state to provide long lasting analgesia.

Privately-held Concentric Analgesics is focused on discovering and developing novel, non-opioid therapeutics for the management of acute and chronic pain.

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Publication:M2 Pharma
Date:Nov 3, 2017
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