Printer Friendly

Compugen receives FDA clearance of IND application for COM902 in patients with advanced malignancies.

M2 PHARMA-November 5, 2019-Compugen receives FDA clearance of IND application for COM902 in patients with advanced malignancies

(C)2019 M2 COMMUNICATIONS

Cancer immunotherapy company Compugen Ltd (NASDAQ:CGEN) reported on Monday the receipt of US FDA investigational new drug (IND) application for its immuno-oncology therapeutic antibody COM902 targeting TIGIT in patients with advanced malignancies.

Upon receipt of IND from the US FDA, the company plans to launch a Phase 1 clinical trial in patients with advanced malignancies for whom standard of care therapies are currently ineffective.

Expected to begin at multiple centres in the US in early 2020, the clinical trial is designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary anti-tumor activity of COM902, according to the company.

COM902, a high affinity, fully human antibody targeting TIGIT, was developed by the company for combination treatment with COM701.

Based on preclinical data, the TIGIT inhibition, either alone or in combination with other checkpoint inhibitors, can enhance T cell activation and increase anti-tumor immune responses. Parallel inhibition of TIGIT and PVRIG results in synergistic effects on effector T cell function and tumor growth inhibition in various model systems that can be further increased with the addition of PD-1 blockade. The TIGT discovery was published by Compugen in October 2009 in the Proceedings of the National Academy of Sciences (PNAS).

((Comments on this story may be sent to info@m2.com))

COPYRIGHT 2019 Normans Media Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2019 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:M2 Pharma
Date:Nov 5, 2019
Words:230
Previous Article:Luye Pharma announces FDA pre-approval inspection with zero observation for LY03004 manufacturing facility.
Next Article:Aeromics partners with Simcere for the development of AER-271 in Greater China for the treatment of stroke.
Topics:

Terms of use | Privacy policy | Copyright © 2019 Farlex, Inc. | Feedback | For webmasters