Printer Friendly

Collagen deficiency may lead to osteoarthritis.

Byline: ANI

Washington, Aug 27 (ANI): In a rodent study, researchers at Duke University Medical Center found that mice, in which the Type IX collagen (Col9a1) gene was inactivated, prematurely developed osteoarthritis (OA) and degenerative disc disease (DDD).

OA and DDD are common, chronic musculoskeletal disorders, which cause joint pain, loss of function, and decreased quality of life.

In the study, the researchers aimed to determine the effect of Col9a1deficiency on functional ability in mice.

Led by Dr. Kyle Allen, the researchers compared the behavioural abilities of Col9a1 deficient mice to wild-type (WT) mice.

They selected mice of advanced age (9-11 months) because they represent an age at which there is histological evidence of OA and DDD.

Functional tests of reflexes, posture, strength, coordination, balance, sensorimotor skills, and gait were conducted to measure physical capabilities that could be impaired due to OA or DDD.

Symptomatic pain was assessed through mechanical and thermal withdrawal thresholds.

"We observed a pattern of behavioral changes in the collagen deficient mice that suggests a relationship to OA- and DDD-like degeneration," stated Dr. Allen. The data shows that mice deficient in Type IX collagen clearly displayed behavioral characteristics of pain and functional loss. These mice had delayed righting reflex (ability to regain footing from a back position), decreased sensorimotor skills, and altered gait compared with WT mice. Collagen deficient mice also had elevated levels of knee and intervertebral disc structural changes.

The study found that collagen deficient mice chose movements that limited peak joint forces and behaviours that reduced pain sensations.

"In future work, these measures may help track signs and symptoms as degeneration progresses. Further studies of the mouse model could provide useful data for evaluating the efficacy of therapeutic interventions for musculoskeletal disorders," said Allen.

Findings of this study appear in the September issue of Arthritis and Rheumatism, a journal of the American College of Rheumatology. (ANI)

Copyright 2009 Asian News International (ANI) - All Rights Reserved.

Provided by an company
COPYRIGHT 2009 Al Bawaba (Middle East) Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2009 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Asian News International
Date:Aug 27, 2009
Previous Article:Chinese boy calls the cops after mum hides laptop!
Next Article:Moily welcomes apex court judges decision to disclose assets.

Related Articles
D-laying arthritis.
Knee implant could ward off osteoarthritis.
Promoting joint health: the undenatured way.
Collagen hydrolysate in joint health.
Hydrolyzed collagen: a versatile protein for joint and bone health, nutrition and beauty.
Do arthritis supplements work? Don't bet your joints on it.
Eggshell membrane new treatment for joint health.

Terms of use | Privacy policy | Copyright © 2018 Farlex, Inc. | Feedback | For webmasters