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Cognitive performance in schizophrenia and bipolar disorder and their first-degree relatives.

124 COGNITIVE PERFORMANCE IN SCHIZOPHRENIA AND BIPOLAR DISORDER AND THEIR FIRST-DEGREE RELATIVES

Due to the several notable similarities in symptoms between bipolar disorder (BD) and schizophrenia (SZ), it can be difficult to effectively distinguish and diagnose between these two illnesses. Neurocognitive performance may be able to serve as a potential trait marker for SZ and BD and can suggest the degree of genetic liability with their first-degree relatives. The objective of the current study was to i) examine differences in cognitive performance among control, SZ and BD patient groups, and their first-degree relatives, ii) find possible predictive values for distinguishing between diagnoses, and to iii) determine the severity of the genetic liability of BD and SZ with their first-degree relatives using neurocognitive performance scores. Using post-hoc statistical comparisons in cognitive tasks, significant differences were observed among the groups, suggesting the ability of cognitive performance to serve as a trait marker with predictive value. With further specificity, significant differences between cognitive domains in subtypes of SZ and BD were also found. As expected, controls displayed the least cognitive deficits compared to SZ, BD, and their first-degree relatives. SZ patients with schizoaffective disorder (SAD) showed the highest level of cognitive impairment in all neurocognitive domains. SZ showed higher cognitive impairment than BD in the domains of attention, visual memory, executive functioning, short memory, and perceptual motor skills. However, patients with SZ displayed better cognitive function than BD in immediate memory, delayed memory, and language.

M. Tran (1) and J.V. Patterson (2). (1) Marina High School, Huntington Beach, CA, 92649. (2) UCI Neuropsychiatric Center, Department of Psychiatry and Human Behavior, UCI Medical Center, Orange, CA, 92868

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Title Annotation:SATURDAY ABSTRACTS IN PROGRAM ORDER
Author:Tran, M.; Patterson, J.V.
Publication:Bulletin (Southern California Academy of Sciences)
Article Type:Author abstract
Geographic Code:1USA
Date:Aug 1, 2014
Words:274
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