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Cognition and fatigue in multiple sclerosis: potential effects of medications with central nervous system activity.

The influence of medications with central nervous system (CNS) effects on cognitive function and fatigue in multiple sclerosis (MS) was evaluated. Investigators compared assessments of cognitive function and fatigue for 70 volunteers. Results showed that MS patients widely used CNS-active medications and only 15 percent did not take any CNS-active medications. Of the participants, 29 percent were taking a selective serotonin reuptake inhibitor, commonly used for depression, and 17 percent were taking an antiepileptic drug, usually to help control pain. Participants who took CNS-active medications were more likely to have cognitive problems, especially with cognitive functions dependent on speed. Ratings of fatigue were also greater in volunteers taking CNS-active medications.

Barry S. Oken, MD, et al.
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Title Annotation:JRRD at a Glance
Author:Oken, Barry S.
Publication:Journal of Rehabilitation Research & Development
Article Type:Brief article
Geographic Code:1USA
Date:Jan 1, 2006
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