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Coenzyme Q10 and creatine combination produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases.

Researchers from the Department of Neurology and Neuroscience at the Weill Medical College of Cornell University have discovered that coenzyme Q10 (CoQ10) and creatine are promising agents for neuroprotection in neurodegenerative diseases via their effects on improving mitochondrial function and cellular bioenergetics and their properties as antioxidants. *

The researchers examined whether a combination of CoQ10 with creatine can exert additive neuroprotective effects in a mouse model of Parkinson's disease, a rat model of Huntington's disease (HD), and a transgenic mouse model of HD. The combination of the two agents produced additive neuroprotective effects against dopamine depletion in the striatum and loss of tyrosine hydroxylase neurons in the substantia nigra following chronic administration of a neurotoxic agent. These findings suggest that combination therapy using CoQ10 and creatine may be useful in the treatment of neurodegenerative diseases such as Parkinson's disease and HD.


* J Neurochem. 2009 Jun;109(5):1427-39.

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Title Annotation:IN THE NEWS
Author:Finkel, Jon
Publication:Life Extension
Article Type:Brief article
Geographic Code:1USA
Date:Mar 1, 2010
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