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Coated aspirin poses problems.

COATED ASPIRIN POSES PROBLEMS. Salicylate poisoning from aspirin may result from accidental overdose ingestion, including suicide attempts, or complication of long-term aspirin theraphy. When enteric-coated aspirin is involved, proper absorption may be delayed and the level of overdosage may not be apparent.

To avoid aspirin reactions in the delicate linings of the stomach, many individuals have been taking enteric-coated aspirin, not realizing that the delayed action in the digestive tract can lead to serious complications.

The enteric coating is composed of acetate phythalate, a substance that remains intact in the acid medium of the stomach and does not dissolve until reaching the alkaline environment of the intestine.

Such gastric retention may delay absorption of the drug. Also, toxic doses of enteric-coated aspirin can result because patients often take larger doses, assuming that the coated version is "safer."

Another possibility is that undissolved tablets accumulate in the stomach of a patient with gastric outlet obstruction, resulting in acute salicylate poisoning. (Based on reports of studies conducted by Robert P. Pierce, M.D., Department of Family and Community Medicine, University of Missouri, Columbia.)
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Title Annotation:Postscripts...
Publication:Nutrition Health Review
Date:Jan 1, 1992
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