CoQ10 levels reduced in septic shock.
An article published in the journal Critical Care documents the finding of decreased levels of coenzyme Q10 (CoQ10) in patients with septic shock.(*)
Harvard researchers utilized data from 14 patients with septic shock who participated in a placebo-controlled trial of statin drugs. Blood samples drawn from the septic patients prior to treatment and from 16 healthy controls were analyzed for coenzyme Q10, low-density lipoprotein (LDL), and vascular endothelial and inflammatory markers.
While the control group had a median CoQ10 level of 0.95 micromoles per liter, which is similar to levels previously measured in healthy patients, the median baseline level for those with septic shock was 0.49 micromoles/liter. Higher CoQ10 levels were associated with lower levels of vascular endothelial biomarkers and inflammatory cytokines, although only vascular cell adhesion molecule (VCAM) and interleukin-10 remained lower following the adjusted analysis.
Editor's Note: Sepsis is an inflammatory state resulting from the spread of infectious agents in the bloodstream. Sepsis and septic shock are major causes of illness and mortality in the US, with over 215,000 deaths occurring each year.
* Crit Care. 2011 Aug 9;15(4):R189.
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|Title Annotation:||IN THE NEWS; coenzyme Q10|
|Article Type:||Brief article|
|Date:||Nov 1, 2011|
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