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CoQ10 improves endothelial function in statin-treated diabetics.

Coenzyme Q10 (CoQ10) improves endothelial function in patients with type 2 diabetes, according to a new report. (1) Coenzyme Q10 is an essential mitochondrial co-factor and natural antioxidant; its synthesis in the body is blocked by the statin drugs widely prescribed to reduce cholesterol levels.


Australian researchers wondered if administering supplemental CoQ10 to type 2 diabetic patients would improve indications of endothelial dysfunction. (1) Characterized by inflammation of the blood vessel linings, endothelial dysfunction is believed to underlie atherosclerosis, which is the foundation of cardiovascular disease.

Twenty-three statin-treated diabetic subjects randomly received either 200 mg CoQ10 per day, or placebo, for three months. Analysis of arterial dilation and markers of oxidative stress revealed that patients receiving CoQ10 experienced a significant improvement in endothelial function, compared with the placebo subjects. (1)

These findings support previous reports that CoQ10 reduces oxidative stress and improves endothelial function. (2,3)


(1.) Diabetes Care. 2009 Feb 19.

(2.) Biofactors. 2008;32(1-4):129-33.

(3.) Eur Heart J. 2007 Sep;28(18):2249-55.

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Title Annotation:IN THE NEWS
Author:Kiefer, Dale
Publication:Life Extension
Article Type:Report
Geographic Code:8AUST
Date:Jul 1, 2009
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