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CoQ10/statin combination improves atherosclerosis treatment.

Russian researchers investigated the effects of combining the statin drug, simvastatin (Zocor[R]) with supplemental coenzyme Q10 for the treatment of coronary atherosclerosis. *


Forty-four patients with coronary atherosclerosis were prescribed daily doses of 90 mg CoQ10 plus 10 mg simva-statin for three months. More than half of the patients had already undergone coronary bypass surgery, while others had undergone coronary angioplasty to improve blood flow to the heart. Other patients' atherosclerosis was diagnosed with coronary angiography.

Beneficial high-density lipoprotein (HDL) increased by 23%, while the "index of atherogenicity" decreased by 27%. CoQ10 treatment reportedly reduced the tendency of platelets to aggregate, while reducing peroxidation of lipids by 30%. Lipid peroxidation is believed to play an important role in the development of atherosclerosis. This effect demonstrated a "potentially independent role of coenzyme Q10 in positive modification of oxidative stress," investigators concluded.


* Chapidze G E , Kapanadze SD, Dolidze NK, Latsabidze NE, Bakhutashvili ZV. Combination treatment with coenzyme Q10 and simvastatin in patients with coronary atherosclerosis. Kardiologiia. 2006;46(8):11-3.
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Title Annotation:IN THE NEWS
Author:Kiefer, Dale
Publication:Life Extension
Article Type:Brief article
Date:Feb 1, 2008
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