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Clinical management of fibroliposarcoma in a buffalo.

Introduction

Fibroliposarcomas are malignant neoplasms composed of lobules of well differentiated adipocytes and fibroblasts. These neoplasms are commonly encountered in dogs and budgerigars, occasionally identified in cats and horses and rarely observed in other domestic species (Aiello, 1998). They generally grow slowly and are well circumscribed (Ogilvie and Moorie, 1995). They generally are soft to spongy on palpation, but may be solid due to presence of fibrous connective tissue, necrosis or inflammation (Moulton, 1990). Infiltrative lipomas also may cause pain, pressure atrophy of muscles and interfere with movement resulting in lameness. The present communication reports a case of fibroliposarcoma of interdigital space in a buffalo.

History and Observation

A 6 year old she buffalo was presented with history of 15cm diameter growth at right Inter digital space with gradual increase in size. The growth was round, ulcerated, hard and gray in colour which interfered with movement of limbs (Fig.1). Haematological and biochemical parameters were within normal physiological limits. Fine needle aspiration biopsy showed malignant lipocytes and fibrous tissue. It was diagnosed as a case of tumor involving interdigital space and was decided to perform surgery.

Treatment and Discussion

The animal was sedated with Xylazine hydrochloride @ 0.01 mg/kg b. wt. intramuscularly. The animal was restrained on lateral recumbency. 2% Lignocaine hydrochloride was infiltrated at base of tumor mass and was excised surgically by using electrocautery. The mass was subjected for histopathological examination. The cut section of mass appeared as firm, oily and glisten. Histopathological examination showed well differentiated lipocytes, acidophilic finely vacuolated cells and interlacing bundles of fibroblasts and closely packed polyhedral cells of single layer fat globule. Variable amount of connective tissue with fatty anaplastic cells was also found (Fig 2).

Surgical excision of tumor mass generally is curative (Ogilvie and Moorie, 1995). Complete resection of infiltrative lipomas is difficult because the tumor margins are often indistinct and neoplasm may infiltrate muscles that are essential to normal function (Kramek et al., 1985).

Intermuscular lipomas that are not infiltrative also have an excellent prognosis after surgical excision (Thomson et al., 1999). Another form of treatment is injection of 30% Calcium chloride (Ca[Cl.sub.2]) directly into small subcutaneous tumors (i.e. liposarcomas with a diameter of <4 cm) (Kramek et al., 1985). Tumor recurrence has been observed in more than 50% of patients within 3 to 16 months following attempted surgical excision. Radiation therapy may be considered post-operatively, especially if residual tumor tissue is suspected (McEntee et al., 2000).

References

Aiello, S.E. (1998). Merck Veterinary Manual. Merck & Co., Inc.,Whitehouse Station, NJ, p. 702-03.

Kramek, B.A., Spackman, C.J. and Hayden, D.W. (1985). Infiltrative lipoma in three dogs. J. Ameri. Vet. Med. Assoc. 186: 81-82.

McEntee, M.C. and Page, L.R. et al. (2000). Results of irradiation of infiltrative lipoma in 13 dogs. Vet Radiol. Ultrasound 41: 554-56.

Moulton, J.E. (1990). Tumors in Domestic Animals, 3rd ed. University of California Press, Berkeley, p. 31-33.

Ogilvie, G.K. and Moore, A.S. (1995). Managing the Veterinary Cancer Patient. Vet Learning Systems, Trenton, NJ p. 486-87.

Thomson, M.J. and Withrow, A.J. et al. (1999). Intermuscular lipomas of the thigh region in dogs: 33 cases. J. Amer. Anim. Hosp. Assoc. 35: 165-67.

R.V. Suresh Kumar (1), P. Veena, P. Sankar and Ch. Srilatha

Department of Veterinary Surgery and Radiology

College of Veterinary Science

Sri Venkateswara Veterinary University

Tirupati--517502 (Andhra Pradesh)

(1.) Corresponding author E-mail:rvsuresh123@rediffmail.com
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Title Annotation:Short Communication
Author:Suresh Kumar, R.V.; Veena, P.; Sankar, P.; Srilatha, Ch.
Publication:Intas Polivet
Article Type:Report
Geographic Code:9INDI
Date:Jan 1, 2014
Words:575
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