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Chronic mitochondrial DNA depletion in peripheral neural cell lines and its implications in peripheral neuropathy.

The mitochondrial DNA deletions and aberrations have been implicated in many peripheral nerve disorders but the lack of a proper model system that gives insights into studying the molecular mechanisms has allowed us to develop an in vitro model that can study the role of mitochondrial DNA depletion in peripheral neuropathy. Chronic depletion of mitochondrial DNA in both Schwann cells and Dorsal root ganglion neurons in vitro has resulted in decreased enzyme activities of various Krebs cycle enzymes including Malate dehydrogenase, Citrate Synthase and a simultaneous increase in Glycolytic pathway enzymes. Our ongoing studies indicate that chronic mitochondrial DNA depletion affects mitochondrial dynamics and shifts the balance towards fission state. Thus, our results may have pathophysiological implications in understanding the role of mitochondrial DNA depletion in peripheral neuropathy.

Vinay Kumar Idikuda (1,2), Alfred O. Isaac (3), Alok Bhushan (1,2) and James C.K. Lai (1,2)

(1) Department of Biomedical and Pharmaceutical Sciences, Idaho State University

(2) Biomedical Research Institute, Idaho State University

(3) Department of Biochemistry, Egerton University, Njoro, Kenya

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Author:Idikuda, Vinay Kumar; Isaac, Alfred O.; Bhusha, Alok; Lai, James C.K.
Publication:Journal of the Idaho Academy of Science
Article Type:Author abstract
Geographic Code:1USA
Date:Jun 1, 2013
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