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Children with bone marrow transplants often have lung problems, study finds.

Children undergoing bone marrow transplantation (BMT) often develop lung problems, a finding that researchers said indicates the need for enhanced monitoring of their pulmonary function.

As survival improves in children with hematologic malignancies treated with BMT, the need to examine potential adverse, long-term effects of therapy becomes increasingly important, according to Isa Cerveri, MD of the University of Pavia in Italy and a multicenter team. The group followed 52 children who received BMT for at least three years, reporting their findings in the February issue of Thorax. Although none of the patients reported chronic respiratory problems at follow-up, "...only 62%...had respiratory function within the normal limits." Specifically, "...23% had a restrictive pattern, and 15% had isolated transfer factor impairment."

Children at highest risk of late pulmonary sequelae included those transplanted after more than one complete remission, those who received an allogeneic rather than autologous transplant, and youngsters with a documented pulmonary infection, the researchers said. "Our results show that more than one-third of survivors of childhood [BMT] have subclinical abnormalities of lung function," Cerveri and colleagues wrote. The authors stressed the need for regular monitoring of pulmonary function after childhood BMT and recommended "...early and aggressive treatment for respiratory illness..." in these patients, long-term follow-up of any lung function abnormalities, and lifetime abstention from smoking.
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Comment:Children with bone marrow transplants often have lung problems, study finds.
Publication:Transplant News
Geographic Code:1USA
Date:Jun 30, 1999
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