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Centers for Disease Control and Prevention updates guidelines for HIV testing.

M2 PHARMA-August 8, 2014-Centers for Disease Control and Prevention updates guidelines for HIV testing


8 August 2014 - The Centers for Disease Control and Prevention (CDC), the national public health institute of the USA, has recently updated its guidelines for HIV testing, on the basis of data reviewed by both CDC and the Association of Public Health Laboratories.

The new guidelines recommend that initial testing for HIV should be conducted with an FDA-cleared fourth generation antigen/antibody combination immunoassay identifying HIV-1 and HIV-2 antibodies and HIV-1 p24 antigen to screen for established infection with HIV-1 or HIV-2 and for acute HIV-1 infection. The guidelines require no additional testing for specimens that are non-reactive on the initial immunoassay.

Furthermore, any specimens that have a reactive or repeatedly reactive antigen/antibody combination immunoassay finding should be analysed with an FDA-authorised antibody immunoassay that distinguishes HIV-1 antibodies and HIV-2 antibodies. Reactive findings on the initial antigen/antibody combination immunoassay and the HIV-1/HIV-2 antibody differentiation immunoassay should be considered as positive for HIV-1 antibodies, HIV-2 antibodies, or HIV-1 and HIV-2 antibodies, undifferentiated.

The new guidelines also recommend that any specimens shown as reactive by the first antigen/antibody combination immunoassay and as non-reactive or indeterminate on the HIV-1/HIV-2 antibody differentiation immunoassay, should then be analysed with an FDA-cleared HIV-1 NAT.

The guidelines further recommend that labs should apply this same testing algorithm, starting with a lab-based antigen/antibody combination immunoassay, to serum or plasma specimens filed for testing following a reactive (preliminary positive) finding from any rapid HIV test.

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Publication:M2 Pharma
Date:Aug 8, 2014
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