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Celladon Secures $30 Million in Series B Financing.

Funding Will Support Clinical Development of Heart Failure Product

LA JOLLA, Calif., Dec. 7 /PRNewswire/ -- Celladon Corporation, a biotechnology company developing treatments for heart failure and other cardiovascular diseases, announced today that it had raised $30 million in a Series B venture financing. The funding will enable Celladon to complete preclinical testing and advance MYDICAR(TM), its product to improve calcium handling in failing hearts, toward Phase 1/2 clinical trials.

New investors Kleiner Perkins Caufield & Byers and Domain Associates led the round. Existing investors Enterprise Partners Venture Capital and Venrock Associates also participated. Dr. Jesse Treu, General Partner of Domain, and Joseph Lacob, General Partner of Kleiner Perkins, have joined Celladon's Board of Directors.

"The investment in Celladon by such high quality investors is testimony to the strong potential of our product and the remarkable progress our team has made since the company was founded 12 months ago," said Celladon Chairman Drew Senyei. "In large animal models of heart failure, MYDICAR(TM) has shown encouraging results. This Series B financing gives us an experienced board and the resources to move the product toward the clinic."

"This financing will support development of Celladon's MYDICAR(TM) gene therapy system, which enhances SERCA2a, an important regulator of myocardial contractility," said Krisztina Zsebo, Celladon's CEO. The SERCA2a gene construct is inserted in Adeno-Associated Virus (AAV) vectors and delivered to the heart percutaneously using a closed-loop oxygenated system. Celladon Corporation is collaborating with Targeted Genetics Corporation on AAV-based manufacturing and gene product development; and with The Baker Heart Research Institute and V-Kardia, Inc. in development of a percutaneous delivery system.

About Celladon

Celladon Corporation is a molecular cardiology company based in La Jolla, California. The company's first product, MYDICAR(TM), combines a gene based therapy with novel percutaneous delivery to enhance calcium cycling in the hearts of patients with congestive heart failure.

CONTACT: Krisztina Zsebo, Ph.D., CEO of Celladon Corporation, +1-858-366-4288

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Publication:PR Newswire
Date:Dec 7, 2005
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