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Cardiac MRI perfusion and viability imaging: clinical value in cardiac care.


Rest-stress perfusion and viability cardiac magnetic resonance imaging (CMRI) tests are performed on a 60-year-old male with known coronary arterial atherosclerotic disease (CAD) (Figures 1-6). Previously, the patient sustained a right coronary artery (RCA) territory myocardial infarction (MI) and underwent successful RCA stent placement. No intervention was performed for left circumflex (LCX) 40% and first obtuse marginal (OM1) 50% stenoses. While the patient is currently asymptomatic, a recent surveillance echocardiography demonstrated worsening global left ventricular function with regional wall-motion abnormalities in the inferior and lateral walls.


CMRI short axis (SAX) (Figure 1), two-chamber (2CH) (Figure 2), three-chamber (3CH) (Figure 3), and four-chamber (4CH) (Figure 4) CINE imaging confirm global mild hypokinesis with proximal apical-inferior wall thinning and akinesis, and mid- and basilar-inferior septum, inferior wall, and posterior-lateral wall myocardial thinning with mild hypokinesis. The best preserved function during rest is in the true apex, most distal apex, and the anterior septum, anterior wall and anterior-lateral wall (apex to base).

Fast-field echo-gradient rest-perfusion images (Figure 5) are remarkable for subendocardial hypoenhancement in the apical-inferior wall and mid- and basilar-inferior septum, inferior wall, and posterior lateral wall. Adenosine fast-field echo-gradient stress imaging subendocardial perfusion, with exception to stress induced subendocardial hypoenhancement in the apical-anterior lateral wall, extending to the junction with the midchamber myocardium (Figure 5).

Inversion-recovery delayed shortaxis images (Figure 6) are remarkable for apical-inferior wall (Figure 6) transmural (> 50%) delayed hyperenhancement (DHE), extending into the posterior-lateral wall, confirming the presence of myocardial scar and focal myocardial nonviability in the RCA territory. In the mid- and basilar-inferior septum, inferior wall, and posterior-lateral wall RCA territory (Figure 6), thin linear < 50% subendocardial DHE is demonstrated, consistent with subendocardial myocardial scar, but with viable myocardium. Of significance, images reveal absence of DHE in the apical-anterior lateral wall (Figure 6), confirming viability and corroborating the presence of stress-induced ischemia in the LCX/OM territory.


Left circumflex coronary artery stress-induced ischemia


CMR myocardial perfusion and viability imaging has become a useful approach to evaluate coronary artery disease. When acquisitions are acquired using current stress and rest perfusion techniques, moderate to high sensitivity (84-100%) and specificity (80-100%) can be achieved for the detection of hemodynamically significant (> 70% stenosis) coronary artery lesions. (1) As illustrated in Figures 1-6, accurate diagnoses can be made to determine the extent and location of myocardial scar and stress induced ischemia, in addition to evaluating cardiac morphology and function. Regions of scar are further characterized as having residual viable myocardium (eg, < 50% of myocardium) or having no viable myocardium (eg, > 50% of myocardium), by determining the burden of scar relative to the myocardium. In patients with known ischemic cardiomyopathy and myocardial scar, CMR stress-rest perfusion and viability imaging can be used to predict future risk for adverse cardiovascular events. (2) In this regard, CMR imaging can be utilized to plan effective therapy for minimizing cardiovascular morbidity and mortality, including medical management, percutaneous coronary intervention (PCI), and coronary artery bypass grafting.


In summary, this patient's perfusionviability CMR imaging demonstrates a small focal area of apical-inferior wall transmural, > 50% myocardial DHE with corresponding akinesis and fixed-perfusion rest-stress defects, corresponding to RCA territory scar with nonviable myocardium, related to the patient's prior MI. In the mid- and basilar-inferior septum, inferior wall, and posterior-lateral wall, < 50% subendocardial DHE with corresponding mild hypokinesis and fixed-perfusion reststress defects, corresponds to RCA scar, but viable myocardium, related to the prior MI.

At the apex, with extension to the junction with the midchamber myocardium, stress-induced ischemia in the LCX/OM territory corresponds to hemodynamically significant CAD. As residual nonhemodynamically significant LCX/OM disease was known from the patient's prior coronary catheterization, CMR imaging suggests progression of disease and supports the need for maximizing CAD medical management and possible coronary catheterization with PCI. The patient ultimately underwent coronary catheterization, which confirmed obstructive LCX disease with no significant change in the OM1 lesion. PCI-LCX stent placement was performed with subsequent improved left ventricular global function on a post-PCI echocardiography.


(1.) Coelho-Filho OR, Rickers C, Kwong RY, Jerosch-Herold M. MR myocardial perfusion imaging. Radiology. 2013; 266:701-715.

(2.) Tsukiji M, Nguyen P, Narayan G, et al. Periinfarct ischemia determined by cardiovascular magnetic resonance evaluation of myocardial viability and stress perfusion predicts future cardiovascular events in patients with severe ischemic cardiomyopathy. J Cardiovasc Magn Reson. 2006;8:773-779.

Jeffrey C. Hellinger, MD, FACC, Zain Kassam, MD, Faton Bytyci, MD, and Gazmend Nura, MD

Prepared by Dr. Hellinger, Dr. Kassam, Dr. Bytyci, and Dr. Nura while at New York Cardiovascular Institute; Lenox Hill Radiology and Medical Imaging, New York, NY.
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Title Annotation:RADIOLOGICAL CASE; magnetic resonance imaging
Author:Hellinger, Jeffrey C.; Kassam, Zain; Bytyci, Faton; Nura, Gazmend
Publication:Applied Radiology
Article Type:Case study
Geographic Code:1USA
Date:Aug 1, 2013
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