Carbapenem-resistant Enterobacteriaceae producing OXA-48-like carbapenemases--United States, 2010-2015.
CDC received reports of52 CRE isolates producing OXA-48like carbapenemases collected from 43 patients in 19 states during June 2010-August 2015 (Figure); seven ofthese isolates were identified retrospectively from six patients. Eight isolates from four patients were part of two different clusters in the United States during 2014. The number of patients from whom CRE isolates producing OXA-48-like carbapenemases were identified ranged from one in 2010 to 11 per year in 2013, 2014, and 2015. Thirty-five patients (81%) had OXA-48-like carbapenemase identified from K. pneumoniae isolates, seven (16%) from Escherichia coli isolates, one (2%) from an Enterobacter aerogenes isolate, and one (2%) from a Klebsiella ozaenae isolate; two of which were isolates of different species from a single patient. Isolates with both New Delhi metallo-[beta]-lactamase and OXA48-like carbapenemase genes were obtained from five patients (12%). The most common sources were urine (22 patients [51%]) and respiratory specimens (nine patients [21%]).
The median age among 35 (81%) patients for whom age was reported was 70 years (range = 29-91 years). Among 29 patients for whom a travel history was available, 19 (66%) had traveled internationally during the year before specimen collection, and 16 (55%) were hospitalized outside the United States for [greater than or equal to]1 night; these percentages increased to 76% and 64%, respectively, when cases associated with the two domestic clusters were excluded. India was the most frequently reported destination among patients with international travel (11 of 19 patients) and international hospitalization (nine of 16).
CRE producing OXA-48-like carbapenemases have demonstrated the ability to spread in other countries (6) and cause outbreaks in health care settings. Factors potentially contributing to the spread of these organisms include the high transfer efficiency of the plasmid containing OXA-48-like genes (6) and challenges in identifying these organisms. These challenges in identification occur because of the limited testing for CRE resistance mechanisms in U.S. clinical laboratories and the different susceptibility profiles of these organisms compared with other carbapenemase-producing CRE, making them difficult to differentiate from CRE that do not produce carbapenemases (organisms producing OXA-48-like carbapenemases might be susceptible to third generation cephalosporins). The modification of the CDC CRE surveillance definition in January 2015 to include organisms that are resistant to ertapenem or that possess a carbapenemase gene should improve sensitivity for detecting OXA-48-producing CRE (7).
Although clusters of CRE expressing OXA-48-like carbapenemases suggest transmission has occurred in the United States, the majority of identified patients were reported to have had exposure to health care outside the United States. This is consistent with recommendations in the CDC Health Advisory from February 2013 (8), which sought to prevent transmission of isolates producing non-R pneumoniae carbapenemases by improving their detection in patients recently hospitalized outside the United States. Recommendations include determining the mechanism of resistance for any CRE isolated from such patients and considering CRE screening of these patients on admission.
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(9.) CDC. FAQs about choosing and implementing a CRE definition. CDC Healthcare-associated infections. Atlanta, GA: US Department of Health and Human Services, CDC. Available at http://www.cdc.gov/hai/ organisms/cre/definition.html.
(10.) CDC Health Alert Network. New carbapenem-resistant enterobacteriaceae warrant additional action by healthcare providers. Atlanta, GA: US Department of Health and Human Services, CDC; 2013. Available at http://emergency.cdc.gov/han/han00341.asp.
Meghan Lyman, MD [1,2]; Maroya Walters, PhD ; David Lonsway, MMSc ; Kamile Rasheed, PhD ; Brandi Limbago, PhD ; Alexander Kallen, MD 
* 2012 CRE Toolkit--Guidance for Control of Carbapenem-resistant Enterobacteriaceae. Available at http://www.cdc.gov/hai/ organisms/cre/cretoolkit/index.html.
 Epidemic Intelligence Service, CDC;  Division of Healthcare Quality Promotion, National Center for Emerging and Zoonotic Infectious Diseases, CDC.
Corresponding author: Meghan M. Lyman, firstname.lastname@example.org, 404-639-4241.
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|Title Annotation:||Notes from the Field|
|Author:||Lyman, Meghan; Walters, Maroya; Lonsway, David; Rasheed, Kamile; Limbago, Brandi; Kallen, Alexander|
|Publication:||Morbidity and Mortality Weekly Report|
|Date:||Dec 4, 2015|
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