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Capsule urea breath test highly accurate for diagnosing H. pylori.

SAN DIEGO -- The capsule urea breath test is more accurate than conventional endoscopic testing and serology for diagnosing Helicobacter pylori infection, results of a study of 100 patients showed.

The test "may become a good alternative to endoscopy for the diagnosis of H. pylori infection," researchers led by Dr. Nan-Jing Peng wrote in a poster presented at the annual meeting of the Society of Nuclear Medicine. "This diagnostic method can avoid contamination of urea from oral urease."

The finding confirms results of a smaller study published by Dr. Peng and her associates last year (World J. Gastroenterol. 2005;11:1361-4).

Dr. Peng, of the department of nuclear medicine at Kaohsiung (Taiwan) Veterans General Hospital, and her associates compared the capsule urea breath test (UBT) with conventional endoscopic testing for the diagnosis of H. pylori in 100 patients. They collected breath samples before and 15 minutes after consumption of capsules containing [.sub.13.C]-urea, and took blood and endoscopic samples for evaluation. They defined patients with H. pylori infection as those with positive culture, or positive results of both histology and the campylobacterlike organism test.

The sensitivity of the capsule UBT was 96.4%, compared with 88.3% and 87.3%, respectively, for endoscopic testing and serology. The specificity of capsule UBT was 100%, compared with 100% and 88.9%, respectively, for conventional testing and serology, the investigators reported.

The accuracy of capsule UBT was 98%, which was higher than that of endoscopic testing (93%) and serology (88%).


San Diego Bureau
H. pylori Test Accuracy

Capsule UBT 98%
Endoscopic testing 93%
Serology 88%

Note: Based on a study of 100 patients.
Source: Dr. Peng

Note: Table made from bar graph.
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Article Details
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Title Annotation:Gastroenterology
Author:Brunk, Doug
Publication:Internal Medicine News
Article Type:Brief article
Geographic Code:1USA
Date:Aug 15, 2006
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