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Cancer risk assessment; chemical carcinogenesis, hazard evaluation, and risk quantification.


Cancer risk assessment; chemical carcinogenesis, hazard evaluation, and risk quantification.

Ed. by Ching-Hung Hsu and Todd Stedeford.

John Wiley & Sons


824 pages




Hsu and Stedeford, both toxicologists who have worked for the Environmental Protection Agency, compile 30 chapters that outline methods to assess human cancer risk from exposure to chemical agents like solvents, metals, mixtures, and nanoparticles. Researchers from North America, Europe, and Japan overview risk assessment, science policy, and the regulatory framework for industrial chemicals and biocides. They present the core concepts, skills, and methods to perform risk assessments, including the fundamentals of cancer biology, chemical carcinogenesis, hormesis, and experimental evidence of thresholds for genotoxic carcinogens; guidelines and regulations for in vitro and in vivo testing; and evaluation of toxicological data and its relevance to hazard evaluation and cancer risk estimation. They then outline methods for quantifying risk, such as quantitative structure-activity relationships, genomics, physiologically-based pharmacokinetic modeling, and computational toxicology, and general approaches like linear and nonlinear low-dose extrapolations, summing tumors, and exposure reconstruction.

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Publication:SciTech Book News
Article Type:Book review
Date:Dec 1, 2010
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