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Calcium and vitamin D improve bone density as well as fracture-preventing drug in men.

The results of a trial reported in Epilepsia reveal a beneficial effect for calcium and vitamin D in helping to protect against the loss of bone density that is associated with the use of antiepileptic drugs.*

Fifty-three men treated with antiepileptic drugs for at least two years prior to enrollment in the Anti-Epileptic Drug and Osteoporosis Prevention Trial (ADOPT) were randomized to receive risedronate (a drug that helps prevent fractures) or a placebo for 12 weeks. All participants received 1,000 to 1,500 mg calcium and 500 to 750 IU vitamin D per day. Bone mineral density was assessed by dual energy x-ray absorptiometry before treatment, and at one and two years.

While participants who received risedronate experienced a 70% improvement in bone density in comparison with values obtained prior to treatment, the improvement in the group that received calcium and vitamin D only (the placebo arm) was nearly as great, at 69%.

Editor's Note: Although risedronate provided

Editor's Note: Although risedronate provided superior results in the current study, the authors caution that treatment with the drug should be limited to five years if possible, in order to avoid the associated risks of jaw osteonecrosis and atypical femoral fractures.

--D. Dye

* Epilepsia. 2013 Sep 6.

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Title Annotation:IN THE NEWS
Publication:Life Extension
Article Type:Brief article
Date:Feb 1, 2014
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