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CT in pregnancy: risks and benefits.

Pregnant patients may experience nonobstetrical emergencies over the course of their pregnancy, including appendicitis, renal colic, ovarian torsion, hemorrhagic ovarian cysts, trauma, and pulmonary embolism. The utilization of computed tomography (CT) in the diagnosis of diseases such as these has increased in recent years, and the same trend is observed in pregnant women. (1) Ionizing radiation is a carcinogen and the increased utilization of CT has been cited as a potential cause for an increase in the prevalence of cancer in developed countries. (2-4) When CT is performed in pregnancy, there is also concern about the teratogenic and carcinogenic effects of ionizing radiation to the developing fetus. In this review article, we will discuss the role of CT in diagnosing nonobstetrical emergency conditions in pregnancy and the risks and benefits to the mother and fetus. For simplicity, we will refer to the conceptus as the fetus. More precisely, the fetus refers to the conceptus after 13 weeks gestational age and the embryo refers to the conceptus before 13 weeks gestational age.

Diagnostic imaging tests

The safest imaging test in pregnancy is ultrasound. It has no known adverse effects on the mother or fetus. It is the first-line imaging test in pregnant patients where applicable.


Plain films result in negligible dose to the fetus when the fetus is not in the field of view. It is recommended that a radiation shield be applied over the gravid uterus for these examinations. Studies through the gravid uterus, such as radiographs of the abdomen and lumbar spine, result in a fetal dose of 1 mGy to 3.5 mGy. (5,6) The background radiation dose to the fetus for 9 months of pregnancy is 0.5 to 1 mGy (6) (Table 1).

CT focuses a collimated beam of X-rays on the body part of interest. When the fetus is not in the field of view, the fetal radiation dose is negligible (Table 1). The fetal dose for a CT head is 0 mGy and for a CT chest is 0.2 mGy or less depending on the trimester of pregnancy. Shielding the gravid uterus does little to reduce the radiation dose to the fetus for CT, but it is often done for reassurance. (6) Concern about the harmful effects of x-rays to the fetus from CT is only considered for those examinations where the gravid uterus is in the field of view. The typical fetal radiation dose for a routine CT of the abdomen and pelvis is 25 mGy. (6) With modern CT scanners that use automated exposure control the dose is about 13 mGy. (7,8) Low-dose CT KUB protocols can result in doses on the order of 10 mGy to 11 mGy (6) (Table 1). Intravenous iodinated and oral contrast may be given in pregnancy. (1,9) Intravenous iodinated contrast is a Food and Drug Administration (FDA) class B agent. Very little iodinated contrast crosses the placenta and enters the fetal circulation. Animal studies have shown no adverse effects to animal pregnancies and no adverse effects have been observed in humans. Thyroid dysfunction in the newborn has not been observed when iodinated contrast has been administered to the pregnant mother intravenously. (1,3) As with all drugs in pregnancy, intravenous iodinated contrast should be administered only if necessary and after informed consent has been obtained.

X-rays are a form of ionizing radiation that has potentially harmful effects on biologically living tissue. Deterministic effects are due to cell death. In the mother, deterministic effects from ionizing radiation include skin erythema, hair loss, and cataracts. They do not occur below a threshold of 1000 mGy (10,11) and are not observed for diagnostic CT scans. In the fetus, deterministic effects include teratogenic effects, such as prenatal death, small head size, mental retardation, intrauterine growth restriction, and organ malformations. These teratogenic effects do not occur below a threshold of 50 mGy to 100 mGy and only occur in the first 15 weeks post-conception (5,6) (Table 2). Above 100 to 150 mGy, the risk is serious enough that one may discuss therapeutic abortion with the mother (5) (Table 3). Since the fetal dose from a CT scan through the abdomen and pelvis is < 50 mGy, teratogenic effects are not a concern to the fetus when exposed to a single exam. They become a concern when multiple exams or multiphase exams are performed.

Stochastic effects are due to DNA damage. In both the mother and fetus, this is carcinogenic. The probability of the effect rather than the severity increases with increasing dose, and there is no threshold below which there is no risk. According to the BEIR VII that studies the survivors of Hiroshima and Nagasaki, the background risk of cancer over the course of an individual's lifetime is 42%. Exposure to 100 mSv of ionizing radiation increases lifetime attributable risk of cancer by 1%. This risk is greater for women and children. It assumes a linear no-threshold risk model and extrapolates back for lower exposures from diagnostic imaging studies. (12) Exposure to 10 mSv ionizing radiation, such as from a CT chest or a CT abdomen, increases one's lifetime attributable risk of cancer by 0.1 %, and this risk is cumulative with serial CT scans performed over one's lifetime. Radiation-induced cancers in those exposed after birth include breast, lung, thyroid, stomach, and colon cancer, as well as leukemia. (2,11,12) This must be taken into account when performing CT scans in pregnant women as in all young individuals. The fetus is more sensitive to carcinogenesis than children and adults and also has a longer life expectancy in which cancers may manifest. Studies of the survivors of Hiroshima and Nagasaki as well as human studies of in utero exposure to diagnostic radiation have demonstrated an increased risk of cancer in children when the fetus is exposed in utero to doses as low as 10 mGy. (5,12,13) The main radiation-induced cancer in childhood is leukemia, but in utero exposure also increases the risk for solid organ cancers. (12,13)

The BEIR VII interpretation of the Oxford Survey of Childhood Cancer indicates that the background risk of cancer death in children is 0.14 % and that exposure to 10 mGy in utero increases the risk of childhood cancer death by 0.06%. (13,14) In other words, there is a 40% increase in childhood cancer with in utero exposures of 10 mGy (relative risk of 1.4). (12) Childhood cancer is often defined as cancer occurring before 15 years of age. According to the ACR Practice Guideline for Imaging Pregnant or Potentially Pregnant Adolescents and Women with Ionizing Radiation from 2008, exposure of the newborn child to 10 mGy of ionizing radiation increases the absolute lifetime risk of developing cancer by 0.4 % and exposure to 50 mGy increases the absolute lifetime risk of developing cancer by 2%, assuming a linear no-threshold model. It is also assumed that this reflects the potential risk to the conceptus in utero for the second and third trimesters and part of the first trimester, although the authors acknowledge that there are uncertainties with this estimate. (15) Nonetheless, the consensus is that for a single CT scan through the abdomen and pelvis that exposes the fetus to 25 mGy of ionizing radiation or less, the risk is low (on the order of 1%) and CT may be performed in patients who have a medically necessary indication.


Organizations involved in radiation concerns in pregnancy have issued key policy statements. In 1977, the National Council of Radiation Protection and Measurements issued the following statement: 'The risk of abnormality (to the fetus) is considered to be negligible at 50 mGy or less when compared to other risks of pregnancy, and the risk of malformations is significantly increased above control levels only at doses above 150 mGy." (16) In 2004, the American Council of Obstetricians and Gynecologists issued this statement: "Women should be counseled that x-ray exposure from a single diagnostic procedure does not result in harmful fetal effects. Specifically, exposure to < 5 rad (50 mGy) has not been associated with an increase in fetal anomalies or pregnancy loss." (17) These statements are supported by the American College of Radiology (ACR). The ACR Appropriateness Criteria for imaging acute pelvic pain in the reproductive age group from 2008 states: "CT should not be withheld in the pregnant patient if deemed clinically necessary to avoid significant delay in diagnosing life threatening conditions, such as appendicitis, bowel perforation, or sepsis." It acknowledges that CT demonstrates the best diagnostic performance in identifying gastrointestinal and urinary tract causes of acute pelvic pain. (18)

Magnetic resonance imaging (MRI) at 1.5 Tesla or less is safe in all trimesters of pregnancy. The safety of MRI at 3.0 T has not been proved and pregnant patients should be imaged at 1.5 T or less. (1,9) Intravenous gadolinium for MRI is an FDA class C agent and should not be given in pregnancy. It crosses the placenta into the fetal circulation and circulates indefinitely. (1,9) Although no adverse effects have been observed in humans, animal studies have shown congenital anomalies in animal offspring exposed in utero. Noncontrast MRI at 1.5 T has a specific role in pregnancy. Of course, it should be used for indications where it is superior to CT. This includes certain neurologic and musculoskeletal indications. It also includes hepatobiliary indications, such as MR cholangiopancreatography (MRCP). The use of MRI in place of CT for conditions usually diagnosed with CT will be discussed in this review.

Nonobstetrical emergencies in pregnancy


Appendicitis is the most common nonobstetrical emergency in pregnancy requiring surgery. (9) The clinical diagnosis of appendicitis is difficult and often delayed in pregnancy. For this reason, the incidence of ruptured appendicitis in pregnancy is greater than in the general population, (9) and the fetal loss rate from ruptured appendicitis ranges from 6% to 37%. (19)



Ultrasound is performed as a first-line imaging test to diagnose appendicitis. When positive, it is a very specific test (Figure 1). Unfortunately, in many cases, ultrasound does not identify the appendix and is nondiagnostic.

Surgical exploration poses risks to the pregnancy by nature of the anesthetics. Therefore, there is a need for preoperative diagnosis of appendicitis with cross-sectional imaging. CT with oral and intravenous contrast is the most sensitive and specific test to diagnose appendicitis (18,20) (Figure 2). It may be performed rapidly to expedite patient care. A single-pass CT scan of the abdomen and pelvis with intravenous and oral contrast ex poses the fetus to 25 mGy ionizing radiation or less. The only risk to the fetus is a small increased risk of childhood cancer (approximately 1% for an exposure of 25 mGy). (15) MRI has a role in diagnosing appendicitis, particularly in the first and early second trimesters before the gravid uterus gets very large. (19) MRI is most useful in identifying a normal appendix and ruling out appendicitis (21) (Figure 3). Unfortunately, the appendix is not con sistently identified with MRI, and MRI may yield equivocal results. It is also unable to demonstrate small extraluminal bubbles of gas from a perforated viscus. Most radiologists are more comfortable making the diagnosis of appendicitis on CT than MRI, and the time to diagnosis is much longer with MRI than CT in most radiology departments.


In summary, if ultrasound is nondiagnostic and the clinical index of suspicion is high, contrast-enhanced CT is probably the next best test to diagnose appendicitis. If ultrasound is nondiagnostic and the clinical index of suspicion is low, or if the patient is in the first trimester or early second trimester of pregnancy and does not have peritoneal signs, one may perform MRI at 1.5 T without intravenous contrast as the next test--provided that the MRI can be performed quickly. Informed consent should be obtained from the patient for both MRI and CT. When obtaining informed consent for MRI, one should discuss the possibility of a nondiagnostic MRI and the potential need for CT.

Renal Colic

Renal colic is the most common nonobstetrical emergency in pregnancy

requiring hospitalization. (9) The clinical diagnosis of renal colic is difficult in many pregnant patients. Delayed diagnosis can lead to preterm labor and infection. Fortunately, most renal calculi pass spontaneously.


The initial diagnostic test for renal colic in pregnancy is usually ultrasound. The most common sign of an obstructing calculus on ultrasound is hydronephrosis. Only rarely can one visualize the obstructing calculus in the ureter. In the second and third trimesters of pregnancy, pregnant women often demonstrate maternal hydronephrosis greater on the right due to compression of the ureters by the gravid uterus. (22) (Figure 4). This limits the radiologists' ability to diagnose renal obstruction on ultrasound in this patient population unless the stone is on the left, in which case one may observe left greater than right hydronephrosis. Ureteral jets are unilaterally absent in several nonobstructed pregnant patients and their detection is of limited diagnostic value. (9)

CT KUB is the most accurate diagnostic test for diagnosing renal colic. (18,20) It may be performed without intravenous contrast. A low-dose CT KUB results in a reduced fetal dose compared to a routine CT abdomen and pelvis with contrast in the order of approximately 10 mGy to 11 mGy. (6,9) If appendicitis is in the differential diagnosis, one could argue that one should perform the scan with intravenous contrast to optimize diagnosis of both conditions and avoid the need for a repeat study. Either way, CT will identify the size and location of the calculus and the degree of hydronephrosis (Figure 5). Once identified, the stone may be followed with serial radiographs. IVP may be safely performed in pregnancy, but is rarely needed and delivers a fetal dose > 50% that of a CT KUB6 (Table 1).

MRI poses the same limitations as ultrasound in the diagnosis of renal colic. It is most useful in detecting hydronephrosis. It is less sensitive in diagnosing the calculus. Time is less of a concern in diagnosing renal colic compared to appendicitis. Therefore, one may attempt an MRI at 1.5 Tesla without intravenous contrast before CT if desired.

Ovarian torsion, hemorrhagic cyst, adnexal mass, degenerating fibroid

Nonobstetrical gynecologic conditions that cause pain in pregnancy may be diagnosed on ultrasound. This includes ovarian torsion, a hemorrhagic corpus luteum cyst, an adnexal mass, and a degenerating fibroid. In each of these situations, if the diagnosis is uncertain with ultrasound, one may perform noncontrast MRI at 1.5 T. (23) If the diagnosis is uncertain on ultrasound and the patient is unstable, for example in the setting of advanced ovarian torsion or a hemorrhagic cyst with hemoperitoneum, one should perform CT without delay to expedite diagnosis (Figure 6).


Pulmonary embolus

Pulmonary embolism occurs with an increasing frequency in pregnancy due to the hypercoagulable state of pregnancy and venous stasis. The mortality from PE is up to 15%. (9) Anticoagulation is associated with an increased fetal morbidity and mortality. The d-dimer may be elevated in normal pregnancies and is less useful in predicting the presence of thromboembolism in pregnant patients than in the nonpregnant population. (9) Therefore, it is important to have an accurate diagnostic imaging test to diagnose PE in pregnancy. Duplex Doppler venous ultrasound is the imaging test of choice to diagnose DVT in pregnancy. CT venography is not recommended in pregnancy to diagnose DVT.

CT pulmonary angiography is preferred over V/Q scanning to diagnose acute PE in the general population because of its higher diagnostic accuracy, lower frequency of inadequate studies, and ability to make alternate diagnoses, such as pneumonia (Figure 7). The ACR guidelines rate both imaging studies the same in pregnancy and advises that the ventilation portion of the V/Q scan be done only if necessary, for example, when the perfusion scan is abnormal (ACR Guidelines for Acute Chest Pain --Suspected Pulmonary Embolism in Pregnancy revised 2011).

The risk to the fetus from ionizing radiation in pregnant patients is low for CTPA and V/Q scans. The fetal dose for a CTPA is 0.003 mGy to 0.13 mGy, depending on the trimester of pregnancy (the dose is greater in the third trimester than in the first trimester). (24) A low-dose technique is often used for V/Q scans in pregnant patients with less radiopharmaceutical and longer acquisition times. The fetal dose for a V/Q scan is up to 0.32 mGy (0.12 mGy for the perfusion scan and 0.2 mGy for the ventilation scan). The dose for both examinations is less than the background radiation dose to the fetus for 9 months of pregnancy that is 0.5 mGy to 1 mGy. (6) Intravenous iodinated contrast is an FDA category B drug and is safe in pregnancy.

The two main concerns with multidetector CTPA in pregnancy are (1) the higher likelihood of inadequate studies than in the general population and (2) the relatively high radiation dose to the maternal breasts and lungs, which are both radiosensitive organs. The whole body effective dose for 16 array or higher multidetector CTPA can be as high as 14 mSv to 20 mSv (4-6) (the effective dose increases with more detectors and the dose is greater in heavier women). (24-26) In comparison, a 2-view mammogram results in a mean glandular dose of 3 mGy. (24) The absorbed dose to the breast for a perfusion scan is 0.28 mGy. (27) A CTPA exam in a young woman can result in a 0.2% to 2.2% increased lifetime relative risk of either breast or lung cancer. (24-26) An added concern in pregnancy is that the breasts of pregnant and lactating women may be more radiation sensitive than those of age-matched controls.7 Dose reduction strategies are being developed in CT to limit the absorbed dose to radiosensitive organs, such as bismuth shields and automated exposure controls that reduce x-ray output when the tube is positioned anterior.


A study by Ridge et al examined the diagnostic adequacy of CTPA examinations in pregnant patients compared to nonpregnant patients and also compared to V/Q scans in pregnant patients with a normal chest x-ray. Perfusion scanning has a high negative-predictive value for PE. It also has a high positive-predictive value. The main limitation of perfusion scanning is the number of inadequate studies, and its inability to make alternate diagnoses. (24) Ridge et al found that the number of inadequate CTPA exams is greater in pregnant patients than in nonpregnant patients largely due to transient interruption of contrast material by unopacified blood from the IVC. They also found that in pregnant patients with a normal chest x-ray, V/Q scan outperformed CTPA in yielding diagnostic examinations. (28) Adequate CTPA examinations in pregnant patients can be obtained more frequently by performing the exam in shallow inspiration or expiration to reduce the inflow of unopacified blood from the IVC. (28)

In conclusion, in pregnant women with a normal chest radiograph, a perfusion scan may be the preferred imaging test to diagnose acute PE. In pregnant women with an abnormal chest radiograph, a CTPA may be the preferred imaging test to diagnose acute PE. For CTPA in pregnancy, the radiologist should utilize bismuth shields (if appropriate for your particular scanner) and automated exposure controls to minimize the absorbed radiation dose to the breasts and breathing strategies to limit the number of inadequate studies.


Trauma is the leading cause of nonobstetric maternal mortality and affects up to 7% of pregnancies. (29,30) Maternal death almost always results in fetal death, and the best chance for fetal survival is maternal survival. All efforts are made to save the mother. Fetal loss occurs with both major and minor trauma. When the mother survives the most common cause of fetal death is placental abruption. (22,31) In high-energy trauma, such as motor vehicle crashes seen at a level I trauma center, the mother is imaged the same as the nonpregnant trauma patient with x-rays, CT, and angiography as necessary. One performs ultrasound to evaluate for free fluid in unstable patients and to date the pregnancy, determine fetal viability, and evaluate the position of the placenta. (32) Contrast-enhanced CT is performed to diagnose traumatic injury to the mother and may also diagnose traumatic injury to the gravid uterus (22,31,33) (Figure 8). In the seriously injured patient, the mother may require several studies with ionizing radiation through the gravid uterus, and the fetal dose may exceed 50 mGy. (8) In trauma patients, the total fetal dose should be calculated by the hospital physicist and recommendations made accordingly. Even in major trauma, it is the rare situation when the fetal dose exceeds the actionable level of 150 mGy when one may need to discuss therapeutic abortion with the mother (Table 3). In low energy trauma, when there is no concern for maternal injury but there is concern for the pregnancy, one performs ultrasound to evaluate the pregnancy and placenta for abruption. Ultrasound is insensitive in diagnosing placental abruption with a high false-negative rate in the order of 50% to 80%. (9,10) The sensitivity of ultrasound in diagnosing placental abruption is 24%. (34) The most useful and reliable test to diagnose placental abruption is external fetal monitoring with devices that measure fetal heart rate and uterine contractility. (35) External fetal monitoring is employed routinely in pregnant trauma patients greater than 24 weeks gestation.


Pregnant patients may experience nonobstetrical emergencies over the course of their pregnancy. A healthy pregnancy requires a healthy mother, and delayed diagnosis of emergencies in pregnancy threaten the mother and her fetus. Ionizing radiation from CT results in a potential increased risk of cancer in the mother and fetus. Ionizing radiation from CT may result in teratogenic effects to the fetus at high doses up to 15 weeks postconception. A CT scan that does not include the gravid uterus in the field-of-view results in negligible fetal dose and may be performed in pregnancy without risk to the fetus. A standard single CT scan through the gravid uterus results in a fetal dose of 25 mGy or less. At this dose, there is no risk of teratogenic effects to the fetus. The only risk to the fetus is a small increased risk of cancer. Intravenous and oral contrast may be given as necessary for CT.


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(3.) Smith-Bindman R, Lipson J, Marcus R, et al. Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancer. Arch Intern Med. 2009;169:2078-2086.

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(6.) McCollough CH, Schueler BA, Atwell TD, et al. Radiation exposure and pregnancy: When should we be concerned? Radiographics. 2007;27:909-917; discussion 917-908.

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(10.) Huda W. Review of Radiologic Physics. Baltimore, Md: Williams & Wilkins; 1995.

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(13.) Doll R, Wakeford R. Risk of childhood cancer from fetal irradiation. Br J Radiol. 1997;70:130-139.

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(15.) Wagner L, Applegate K. ACR Practice Guideline for Imaging Pregnant or Potentially Pregnant Adolescents and Women with Ionizing Radiation. 2008:1-15. Pregnancy.aspx

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Claudia T. Sadro MD, FABR, FRCPC, Theodore J. Dubinsky MD

Dr. Sadro is in the Department of Radiology, Harborview Medical Center, Seattle WA, and Dr. Dubinsky is at the University of Washington, Seattle, WA.
Table 1. Fetal absorbed doses from selected procedures *

X-Ray Examinations              Fetal Absorbed Dose (mGy)
Cervical spine (AP, lat)                   <0.001
Chest X Ray (PA, lat)                       0.002
Thoracic Spine X Ray (AP, lat)              0.003
Abdomen X Ray (AP)                           1-3
Lumbar Spine X Ray (AP, lat)                  1
Limited IVP                                   6
Barium Enema                                  7
CT Examinations ([dagger])       Fetal Absorbed Dose (mGy)
CT Head                                       0
CT Pulmonary Angiogram                       0.2
CT Abdomen                                    4
CT Abdomen Pelvis                            25
CT KUB                                       10

Background for 9 months of                 0.5 - 1
  pregnancy ([dagger])

* There are several measurements for radiation
dose. The absorbed dose is measured in the rad and
the effective dose is measured in the rem. In the
international system of units, the rad is measured
as the Gray (Gy) and the rem is measured as
the Sievert (Sv). 1 rad = 10 mGy and 1 rem = 10
mSV. (1)

([dagger]) CT doses to conceptus and
background dose to the conceptus obtained from
McCollough CH, Schueler BA, Atwell TD, et al.
Radiation exposure and pregnancy: when should we
be concerned? Radiographics. 2007;27:909-917;
discussion 917-908 (Reduced dose protocol for CT

Table 2. In utero effects of diagnostic levels of ionizing
radiation (0-250 mGy) *

Gestational age     Stage of development

0-2 weeks           Pre-implantation

1-8 weeks           Major organogenesis

2-8 weeks           Major organogenesis

2-15 weeks          Organogenesis and rapid
                    neuronal development
                    and migration
8-15 weeks          Rapid neuronal development
                    and migration
2 weeks to term     Post-implantation

Gestational age     Biologic effects to conceptus

0-2 weeks           Prenatal death (all or none)
                    Risk at > 50-100 mGy (animal studies)
1-8 weeks           Intrauterine growth restriction
                    Risk at > 200 mGy (animal studies)
2-8 weeks           Organ malformations > 100 mGy, but
                      not observed in humans at
                      diagnostic levels.
2-15 weeks          Small head size (SHS) (not necessarily
                      decreased IQ) 100 mGy threshold observed
                      in animals, no threshold observed in
                      Hiroshima survivors
8-15 weeks          Severe mental retardation (SMR)
                    Not observed < 10 mGy and a threshold
                      of 100 mGy is assumed.
2 weeks to term     Childhood cancer (< 15 years old)
                    Risk of childhood cancer death 0.06 %
                     per 10 mGy ([double dagger])
                    Risk of childhood cancer 0.4 % per 10 mGy
                    No threshold.

* Source: Wagner LK, RG Lester and LR Saldana.
Exposure of the Pregnant Patient to Diagnostic
Radiations. A Guide to Medical Management. Second
Edition. Medical Physics Publishing, Madison WI,
1997. Chapter 4: Prenatal risks from ionizing
radiations, ultrasound, magnetic fields and
radiofrequency waves. pp 77-106.

([dagger]) The gestational age of the pregnancy is the number of
weeks since the mother's last menstrual cycle. It
is the number of weeks post conception plus 2

([double dagger]) Background risk of
childhood cancer death 0.14%. (11)

([section]) Absolute lifetime risk of cancer 0.4% per 10 mGy. (15)

Table 3. Guidelines for managing pregnant women exposed to diagnostic
radiation *

                   Radiation dose  Adverse biological effects

< 2 weeks          < 50 mGy        None
post conception    > 50-100 mGy    Possible spontaneous abortion
2-15 weeks         < 50 mGy       Minimal risk
post conception                   Childhood cancer (childhood cancer
  ([dagger])                      death 0.06% per 10 mGy)

                                  Absolute cancer risk (0.4 % per 10
                                    mGy) ([double dagger])

                   50-150 mGy     Small head size (0.5-1% per 10
                                  Mental retardation (0.4% per 10
                                  Childhood cancer (childhood cancer
                                  death 0.06% per 10 mGy)
                                  Absolute cancer risk (0.4 % per 10
                                    mGy) ([double dagger])
                   > 150 mGy      Small head size (15% risk)
                                  Mental retardation (6% risk)
                                  Childhood cancer (childhood cancer
                                  death 0.06% per 10 mGy)
                                  Absolute cancer risk (0.4 % per 10
                                    mGy) ([double dagger])
> 15 weeks         Any            Childhood cancer (childhood cancer
post conception                   death 0.06% per 10 mGy)
                                  Absolute cancer risk (0.4 % per 10
                                    mGy) ([double dagger])

Gestational age    Recommendation

< 2 weeks          None
post conception    None
2-15 weeks         None
post conception
                   Generally, therapeutic abortion is not
                   recommended. However, it may be
                   considered with exposures > 100 mGy
                   in the setting of other risk factors, such
                   as acute viral infection or exposure
                   to teratogenic drugs.
                   Counsel mother about possible
                   therapeutic abortion.

> 15 weeks         None
post conception

* Source: Wagner LK, RG Lester and LR Saldana.
Exposure of the Pregnant Patient to Diagnostic
Radiations. A Guide to Medical Management. Second
Edition. Medical Physics Publishing, Madison WI,
1997. Chapter 10 Stage III The Decision, pp

([dagger]) For 2-8 weeks post conception at
> 100 mGy, there is a risk of organ malformations,
but organ malformations have never been observed
in humans at diagnostic levels.

([double dagger]) Applegate K and LK Wagner. ACR Practice Guideline
for Imaging Pregnant or Potentially Pregnant
Adolescents and Women with Ionizing Radiation. In:
Resolution (26): American College of Radiology,
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Title Annotation:computed tomography
Author:Sadro, Claudia T.; Dubinsky, Theodore J.
Publication:Applied Radiology
Article Type:Clinical report
Geographic Code:1USA
Date:Oct 1, 2013
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