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CRP levels and air pollution during pregnancy.

Exposure to air pollution has been associated with higher levels of C-reactive protein (CRP), which suggests an inflammatory response. van den Hooven et al. (p. 746) investigated the association of air pollution exposure during pregnancy with maternal and fetal CRP levels in a population-based cohort study in the Netherlands. P[M.sub.10] and nitrogen dioxide (N[O.sub.2]) levels were estimated at the home address using dispersion modeling for different averaging periods preceding the blood sampling. CRP levels were measured in maternal blood samples in early pregnancy (n = 5,067) and in fetal cord blood samples at birth (n = 4,450). Compared with the lowest quartile, higher P[M.sub.10] exposure levels for 1 and 2 weeks before delivery were associated with elevated maternal CRP levels (> 8 mg/L) in the first trimester, but no clear dose response relationships were observed. P[M.sub.10] and N[O.sub.2] exposure levels-for 1, 2, and 4 weeks preceding delivery were not consistently associated with fetal CRP levels at delivery. However, higher long-term P[M.sub.10] and N[O.sub.2] exposure levels (total pregnancy) were associated with elevated fetal CRP levels (> 1 mg/L). The authors conclude that air pollution exposure during pregnancy may be associated with maternal and fetal inflammatory responses.

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Title Annotation:CHILDREN'S HEALTH
Publication:Environmental Health Perspectives
Article Type:Brief article
Geographic Code:1USA
Date:May 1, 2012
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