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CLINICAL AND IMMUNOLOGICAL CHANGES IN ORAL CAVITY WITH HERPETIC STOMATITIS AFTER THE COMPLEX THERAPY WITH ACRIDON-ACETIC ACID AND N-METHYLGLUCAMINE.

Introduction: the clinical and pathogenetic efficiency of Cycloferon liniment containing acridone acetic acid--50.0 mg and N-methylglucamine (meglumin)--38.5 mg in the complex therapy of herpetic stomatitis (HS) was studied.

Aim: to study and evaluate the effectiveness of liniment containing acridone acetic acid - 50.0 mg, N-methylglucamine (meglumin) - 38.5 mg in the complex therapy of viral stomatitis in the immediate and long-term period of treatment.

Methods: Cycloferon liniment was used to treat patients with herpetic stomatitis. We examined 40 patients with HS in age from 19 to 38 years old, who were divided into two groups. Liniment containing acridone acetic acid - 50.0 mg, N-methylglucamine (meglumine) - 38.5 mg in the form of applications of impregnated cotton turunds for 20 minutes was added to the complex treatment in 1st group (main group - 20 people), the therapy with liniment lasted 10 days (2 applications per day on the oral mucosa). In the 2nd group (control group - 20 people), therapy of herpetic stomatitis was carried out with the use of standard methods. In both groups, etiotropic treatment of HS was carried out using valacyclovir tablets - 500.0 mg (2 times a day).

Phagocytic index, the level of lysozyme and of secretory immunoglobulin A (sIgA) in saliva were determined to study the factors of local protection

Results: an objective examination of all patients in the main group showed that there was no pain during palpation, swelling of the mucous after the full treatment (10 visits). Healing of aphths was noted at 18 people. All patients subjectively felt better, noted the disappearance of pain and an unpleasant smell from the oral cavity. During next 6 months, there were not relapses of the disease in the main group.

15 patients in the control group, by the 10th visit, subjectively felt better, noted the disappearance of an unpleasant smell from the oral cavity. 8 patients still had the pains in the mucous during food intake and tooth brushing. An objective examination showed the decrease of the pain of the mucous in 17 patients, the healing of aphths was noted in 15 patients. The absence of any signs of convalescence was noted in 1 patient. 4 patients had relapses of the disease.

Study of the indicators of factors of local protection of the oral mucosa showed that the most significant changes were in phagocytosis, which were almost twice low comparing to the norm. The level of lysozyme and sIgA were 1.5 time reduced comparing to the norm. These data indicate the development of secondary immunodeficiency in the oral mucosa in herpetic stomatitis.

Conclusions: the use of liniment containing acridone acetic acid - 50.0 mg, N-methylglucamine (meglumin) - 38.5 mg in complex treatment of HS reduces the severity of local inflammation, normalizes the parameters of local immunity that accelerates healing processes and provides the decrease of the frequency of relapse of stomatitis. Clinical results of the use of the liniment in the complex treatment of patients with viral stomatitis were significantly better than in control group.

J. Babadjanov (1), S. Agzamkhodjaeva (2)

(1) Tashkent State Dental Institute (2) Republican Dermato-venerologic hospital

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Author:Babadjanov, J.; Agzamkhodjaeva, S.
Publication:Journal of Asian Medical Student Association
Article Type:Report
Geographic Code:9UZBE
Date:Jun 1, 2019
Words:516
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