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Bullous Lesion Marks Valproic Acid Poisoning.

NEW ORLEANS -- A healthy 4-year-old exhibited symptoms of valproic acid poisoning concurrently with ecchymotic skin lesions, some of which became bullous, Dr. Elizabeth A. Christ reported in a poster presentation at the Southern regional meeting of the American Federation for Medical Research.

Although skin reactions can occur from therapeutic doses of valproic acid, severe reactions to it are rare, compared with other anticonvulsants, said Dr. Christ of the University of Mississippi Medical Center, Jackson.

The child, who arrived at the hospital in a state of coma and shock, displayed bone marrow suppression, rhabdomyolysis, and hepatocellular injuries which were symptomatic of acute valproic acid poisoning.

Several ecchymotic lesions were observed. Additional lesions developed within 1 week, and several became bullous. However, as valproic acid levels dropped, the lesions resolved, hemodialysis was unnecessary, and the patient made a complete recovery

This may be the first reported case of bullous lesions associated with acute valproic acid poisoning, Dr. Christ noted.

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Author:Splete, Heidi
Publication:Pediatric News
Geographic Code:1USA
Date:Jul 1, 2001
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