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Bruker Daltonics Introduces Suite of New Proteomics Products at the American Society for Mass Spectrometry Conference.

Business/Technology Editors & Health/Medical Writers

CHICAGO--(BW HealthWire)--May 27, 2001

Bruker Daltonics Inc. (NASDAQ: BDAL) today announces several major product introductions for proteomics at the American Society for Mass Spectrometry (ASMS) conference.

"We continue to develop and commercialize innovative life-science products at a rapid rate," commented Dr. Frank H. Laukien, President and CEO. "I am excited about our new proteomics products introduced at ASMS, and believe that they will be very well accepted by customers due to their significant advantages in terms of performance and productivity."


Bruker Daltonics introduces BioTOF(R)-Q, a novel ultra-high performance electrospray ionization (ESI) mass-selective quadrupole / collision quadrupole / time-of-flight analyzer (Q-q-TOF) mass spectrometer.

-- The BioTOF-Q adds tandem mass spectrometry (MS/MS) capabilities to our BioTOF II high-resolution ESI-TOF system.

-- Tandem mass spectrometry using a Q-q-TOF geometry permits the sensitive and highly accurate determination of molecular fragments in proteomics identification, de novo peptide sequencing, complex mixture analysis and other life-science applications.

-- The new BioTOF-Q system is unique due to its revolutionary, patented COMPASS(TM) method for significantly improved mass resolution greater than 20,000, and better mass accuracy than other Q-q-TOF systems.


At the same time, Bruker Daltonics announces its next-generation research-grade esquire3000 plus(TM) electrospray ionization (ESI) ion trap. The esquire3000 plus, developed in collaboration with Agilent Technology, features a new ion transfer mechanism for higher ion flux and significantly increased sensitivity.

-- The esquire3000 plus offers the highest performance for the requirements of drug discovery and LC/MSn researchers. Particularly for proteomics applications, the overall sensitivity is improved by one order of magnitude.

-- The esquire3000 plus provides new and superior data processing capabilities like PepMassCreator(TM), or the innovative SmartSuite(TM) for an intuitive workflow.

-- The esquire3000 plus continues to offer the highest standard mass range up to m/z = 3,000 without using lower-sensitivity "extended mass range" switching. It also provides the best combination of resolution and scan speed available. Both features are of significant importance in high-throughput proteomics.


In order to provide a comprehensive proteomics solution, Bruker Daltonics introduces its innovative Proteineer(TM) suite of consumables, robotics, mass spectrometry systems and bioinformatics modules for proteomics. The Proteineer suite offers the unique combination of the two most powerful high-throughput proteomics methods of mass spectrometry for the protein identification funnel paradigm that is now widely accepted in proteomics facilities.

Therefore, in addition to front-end sample preparation automation tools, consumables and robotics, the unique Proteineer concept offers the integrated use and adaptive intelligent acquisitions strategies for efficient protein identification by

-- our leading ultra-high throughput MALDI-TOF systems as a first protein identification assay,

-- an optional MALDI-TOF MS/MS 2nd assay for a quantum jump in protein identification productivity, as well as

-- robust high-performance ion trap ESI/MSn as a third assay for protein identification, determination of post-translational modifications, to obtain increased sequence coverage, for the identification of proteins in mixtures, and for protein quantitation.

Bruker Daltonics believes that this is the most suitable and productive combination of tools for high-throughput proteomics by mass spectrometry.


An important new module of our Proteineer suite of proteomics tools is the newly-introduced mac(TM) (MALDI Automated Gel Cutter), which integrates imaging of the gel, visual analysis, spot selection, and cutting of spots out of 2D gels used for protein separations. The mac automates and simplifies many of the otherwise tedious tasks in preparing samples prior to MALDI-TOF-MS or ESI-MS/MS analysis of proteins.

-- mac is based on our successful map(TM) II MALDI AutoPrep system, and further extends the Bruker Daltonics proteomics sample preparation robotics offering.

-- An advanced digital scanner is incorporated for gel imaging and visualization.

-- mac control software utilizes EXCEL spreadsheets, incorporates a viewer to visualize the gel image, and allows manual editing of the spot list to be excised.

-- mac control is modular and also supports other commercial spot picking software for automatic and/or manual spot detection.


As a fifth new product, Bruker Daltonics announces ProteinScape(TM), a bioinformatics software package for comprehensive proteomics data warehousing and analysis, developed in collaboration with leading pharmaceutical and proteomics research companies.

-- ProteinScape provides a web-based client-server platform for storing, organizing and analyzing data generated in the entire workflow of proteomics. It operates with industry standard relational database systems.

-- ProteinScape automatically collects data including gel objects from gel imaging software. It supports a modular and flexible approach to bioinformatics queries by supporting different search engines in the protein identification step.

-- ProteinScape's integration of Bruker Daltonics` program BioTools(TM) provides a clear and comprehensive view into the protein identification process.

-- ProteinScape allows auto-annotation of protein assignments in gel images, direct linkage of gel-spots to acquired spectra and other related database entries for rapid navigation and viewing the results of the proteomics workflow.

-- Via direct links to public annotated protein databases ProteinScape gives immediate access to additional relevant information.


Bruker Daltonics is a leading developer and provider of innovative life science tools based on mass spectrometry. Its substantial investment in research and development allows it to design, manufacture and market a broad array of products intended to meet the rapidly growing needs of a diverse customer base, including pharmaceutical companies, biotechnology companies, proteomics companies, molecular diagnostics companies, academic institutions and government agencies. Bruker Daltonics has diverse technology platforms which integrate automated sample preparation and clean-up, advanced front-end AnchorChip MALDI targets and API source technology with cutting-edge proprietary MALDI-TOF, ESI-TOF, ion trap and FTMS mass analyzers, as well as analysis and bioinformatics software. Bruker Daltonics is also a worldwide leader in supplying mass spectrometry-based systems for substance detection and pathogen identification in security and defense applications.


All statements in this press release that are not historical are forward-looking statements within the meaning of the Securities Exchange Act of 1934, as amended, including, but not limited to, statements regarding Bruker Daltonics' "expectations," "beliefs," "hopes," "intentions," "strategies" or the like. Such forward-looking statements are subject to risks and uncertainties that could cause actual results to differ materially for Bruker Daltonics from those projected, including, but not limited to, risks and uncertainties relating to technological approaches, product development, manufacturing, market acceptance, cost and pricing of Bruker Daltonics' products, dependence on collaborative partners, suppliers, FDA and other regulatory approvals to the extent applicable, competition, the intellectual property of others, patent protection and litigation and other risk factors discussed from time to time in Bruker Daltonics' reports or filings with the Securities and Exchange Commission. Bruker Daltonics expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Bruker Daltonics' expectations with regard thereto or any change in events, conditions, or circumstances on which any such statements are based.
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Date:May 27, 2001
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