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Brain function and connectivity correlated to corpus callosum. (In Alzheimer's and Schizophrenia).

BALTIMORE -- Patients with either Alzheimer's disease or schizophrenia have a lower level of interhemispheric brain connectivity that is correlated with a smaller size in specific areas of the corpus callosum, Dr. Oliver Pogarell said at a conference on clinical electrophysiology sponsored by the EEG and Clinical Neuroscience Society.

He and his colleagues studied the size of the corpus callosum in 11 moderately demented patients with Alzheimer's using structural MRI scans. In their ongoing study, they compared these measurements with the coherence (the synchronization of different sets of cortical sites) between the two hemispheres of the brain. The highest level of coherence between brain cortical sites--found in the alpha frequency bands of EEG readings from the posterior occipital lobe--was significantly positively correlated with a larger total size in the corpus callosum, said Dr. Pogarell of the department of psychiatry at the University of Munich.

Some coherences between cortical sites were correlated to the sizes of different regions in the corpus callosum. The coherence of alpha and beta frequency bands in occipital cortical sites were significantly positively correlated with the size of the C5 region of the corpus callosum. Coherence in the alpha-2, delta, and theta frequency bands between frontal cortical sites were significantly positively correlated to the size of anterior regions of the corpus callosum. The correlations were independent of patient age and score on the Mini-Mental State Examination.
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Author:Evans, Jeff
Publication:Clinical Psychiatry News
Article Type:Brief Article
Geographic Code:1USA
Date:Feb 1, 2003
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