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Brain cancer's 'cellular origin' may help thwart 'deadly' attack.

Washington, July 8 (ANI): A research team has identified the cellular origin of malignant glioma, a deadly human brain cancer.

Researchers at the University of Oregon and Stanford University, led by UO biologist Hui Zong, used a mouse genetic system to carry out their experiment successfully.

According to the researchers, the oligodendrocyte precursor cells (OPCs) are the first cells to display 'significant overexpansion and aberrant growth'.

"The cure for this devastating disease lies in our ability to unequivocally identify the cell-of-origin for gliomagenesis, which would then allow researchers and doctors to harness the intrinsic properties of such cell types to thwart the attack," said Zong.

The technique Zong and his team used was Mosaic Analysis with Double Markers (MADM), developed for studying developmental biology and modeling diseases in mice.

The MADM allowed Zong's team to probe into pre-clinical, tumor-initiating stages that are inaccessible to researchers using conventional tools.

"Our system lets us watch the action from the beginning, to watch every direction, every hand off or pass, before a tumor forms," added Zong.

The study is reported online ahead of regular print publication in the July 22 issue of the journal Cell. (ANI)

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Publication:Asian News International
Date:Jul 8, 2011
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