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Both self-collected, clinician-collected vaginal swabs good for HPV testing: adolescent population.

ST. LOUIS -- Vaginal swabs self-collected by adolescents appear to be a reasonable alternative to clinician-collected cervicovaginal swabs when testing for human papillomavirus, Dr. Jessica Kahn reported at the annual meeting of the Society for Adolescent Medicine.

Because the results of self-collected and clinician-collected samples didn't differ significantly, self-collection might increase screening among adolescents who are averse to speculum exams or who are seen in nontraditional settings, said Dr. Kahn of Children's Hospital Medical Center, Cincinnati.

She examined agreement in human papillomavirus (HPV) identification in 99 paired samples collected from 101 females aged 14-21 years; two of the samples did not amplify. The patients were seen at an urban teen health center. Their mean age was 17 years; 84% were black. Their mean number of lifetime sexual partners was six; 27% had a history of abnormal cervical cytology.

The self-collected and clinician-collected samples did not differ significantly in identifying the number of high-risk strains, the percentage of patients with high-risk strains, or the number of HPV strains per patient.

In identifying the presence of low- or high-risk HPV, or the absence of HPV, the samples were concordant in 84 of the 99 sets. In identifying HPV types, there was complete agreement in 77 sets of samples, partial agreement (both samples identified at least one of the same strains) in 6%, and no agreement in 18%. There were no significant differences in results when they were stratified by patient age.

The two types of samples retrieved had similar sensitivity and specificity for both atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesions (see box).

Detecting Abnormal Cytology With
Self- and Clinician-Collected Samples

           Sensitivity        Specificity
        Self   Clinician   Self   Clinician

ASCUS   0.70      0.70     0.62      0.66
LSIL    0.63      0.63     0.56      0.60

Notes: ASCUS, atypical squamous cells of undetermined significance;
LSIL, low-grade squamous intraepithelial lesions.

Source: Dr. Jessica Kahn
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Article Details
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Title Annotation:Infectious Diseases; human papillomavirus
Author:Sullivan, Michele G.
Publication:Pediatric News
Geographic Code:1USA
Date:Jun 1, 2004
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