# Bonferroni [bon'far-o"ni] correction.

Named after Italian mathematician Carlo Emilio Bonferroni (1892-1960) but first attributed to Olive Jean Dunn, the Bonferroni correction compensates for multiple comparisons by dividing the significance level by the number of comparisons. The significance level is the probability that a given test will incorrectly find a difference in the sample that is not present in the population (false positive). A significance level of 0.05 is a commonly accepted significance level. If a study tested 5 comparisons, there would be up to a 25% likelihood (0.05 + 0.05 + 0.05 + 0.05 + 0.05) that any one of them would show a significant difference by chance. The Bonferroni correction adjusts for this by dividing the significance level by the number of tests. In this case, the significance level for a given comparison would be 0.01, for an overall risk no larger than 0.05 of falsely detecting a difference.

This technique has been criticized as too conservative, particularly when a large number of tests are used, and it may increase the risk for a false negative. Other tests, such as the Tukey-Kramer and Scheffe method, may reduce this risk.

Sources

1. Bland JM, Altman GD. Multiple significance tests: the Bonferroni method. BMJ. 1995;310:170. http://dx.doi.org/ 10.1136/bmj.310.6973.170

2. Dunn OJ. Multiple comparisons among means. J Am Stat Assoc. 1961;56:52-64. http://dx.doi.org/10.1080/01621459.1961.10482090

3. Perneger TV. What's wrong with Bonferroni adjustments. BMJ. 1998;316:1236-8. http://dx.doi.org/10.1136/ bmj.316.7139.1236

4. Sedgwick P. Multiple hypothesis testing and Bonferroni's correction. BMJ. 2014;349:g6284. http://dx.doi.org/10.1136/bmj.g6284

Address for correspondence: Ronnie Henry, Centers for Disease Control and Prevention, 1600 Clifton Rd NE, Mailstop E03, Atlanta, GA 30329-4027, USA; email: boq3@cdc.gov

DOI: http://dx.doi.org.10.3201/eid2102.ET2102

COPYRIGHT 2015 U.S. National Center for Infectious Diseases
No portion of this article can be reproduced without the express written permission from the copyright holder.