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Black carbon, blood pressure, and miRNA-related SNPs.

Exposure to particulate air pollution has been associated with cardiovascular morbidity and mortality in epidemiologic studies. There is growing evidence that traffic-related pollution, including black carbon (BC), may drive the cardiotoxic effects observed in response to air pollution, although results have been inconsistent. There is also evidence that key regulators of gene expression, such as microRNAs, may affect pathogenic pathways for cardiovascular disease. Wilker et al. (p. 943) hypothesized that individual susceptibility to BC may be related to polymorphisms in genes that regulate miRNAs. The authors investigated the association between BC exposure and blood pressure, as well as potential effect modification by single nucleotide polymorphisms (SNPs) in microRNA-processing genes. Using data from the Normative Aging Study, they report that a 1-SD increase in BC was associated with elevated systolic and diastolic blood pressure. Associations with diastolic blood pressure were modified by SNPs in the DICER, GEMIN4, and DGCR8 genes, and associations with systolic blood presure were modified by SNPs in GEMIN3 and GEMIN4. The authors suggest that findings support a role for miRNA genesis and processing in effects of BC on blood pressure.

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Title Annotation:Research; single nucleotide polymorphisms
Publication:Environmental Health Perspectives
Article Type:Brief article
Geographic Code:1USA
Date:Jul 1, 2010
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