Big bores or big bores.
For the sake of those few .41 caliber aficionados left I'll admit the .41 Magnum to the big-bore category. Actually if considered a medium bore it would be at the top of the heap. As a big bore it's at the bottom of the stack where it belongs. The top of the stack are the .50 calibers--with exceptions of course. I've developed the .620 JDJ, which uses a 1,050 grain bullet at about 1,050 fps and is legally a Destructive Device. requiring a $200 Federal Tax Stamp. While 1.050 fps is fun. 1,200 fps gives all the fun I can stand. In general, bigger is usually considered better--unless it's too big, of big--but lacking in strength.
The .44 Special and .45 Colt factory RNL ammo is low in velocity and recoil and particularly--if re-crimped--the WW RN ammo is wonderfully accurate if you have an accurate revolver. For ordinary fun, tin can shooting, it's great. For anything else it is big-BORING! While found in lightweight revolvers, it shouldn't be hot-rodded in them, and CorBon .45 Colt (Magnum) ammo should not be used. Handloaded in suitable modern revolvers, both can become relatively powerful rounds fully capable of taking big game at the expense of additional recoil.
The .454 Casull could be considered a .45 Colt Magnum and the full-length .460 S&W a Super Magnum. Normally the .454 is found in the excellent but fairly light Freedom Arras revolver, and the .460 in the big, heavy S&W revolver. The lightweight Freedom gun recoils pretty heavily and the .460--while giving slightly more ballistic "power"--recoils less due to its very heavy weight and large size.