Bibliometric Analysis of the Most Cited First One Hundred Manuscripts in Familial Mediterranean Fever/Ailesel Akdeniz Atesi Konusunda En Fazla Atif Alan Ilk Yuz Makalenin Bibliyometrik Analizi.
Objective: Studies investigating cumulative scientific data about a specific subject and assessing the scientific performance are named as bibliometric analysis. Familial Mediterranean Fever (FMF) is an autosomal recessive disease which is more prevalent among Turks, Jews, Armenians and Arabs. In this study, we aimed to analyse the most cited first 100 manuscripts in the field of FMF using bibliometric method.
Materials and Methods: This study was performed retrospectively by using "Thomson Reuters Web of Science" database in April 2016. The dataset was filtered to include the manuscripts only in the scope of "Science Citation Index Expanded (SCI-E)". Furthermore, the first most cited 100 manuscripts were analyzed in terms of topic, journal, author, year and institution.
Results: The database search returned 2027 manuscripts and the most cited first 100 papers were included. The most cited paper focused on genetics of FMF. Among these most cited 100 manuscripts, the study by Livneh had the highest volume of total citations with 1198. These most cited manuscripts were published in 44 journals. When these publications were evaluated in terms of countries, Israel had the most cited manuscripts with 37%, Turkey and USA with 18%, and France with 12%.
Conclusion: This work provides the most influential references related to FMF and serves as a guide to what makes a publication citable. The genetics of FMF was the most widely studied topic and Israel, Turkey, USA and France were revealed as the arbiter countries of FMF topic.
Keywords Familial Mediterranean Fever, citation, bibliometric analysis
Amac: Spesifik bir konuda birikmis bilimsel verileri inceleyerek, o konu ile ilgili bilimsel performansi degerlendiren calismalara bibliyometrik calismalar denir. Bibliyometrik calismalar literaturlerin yakin takibini saglarken arastirmacilarin yeni planlayacaklari calismalar icin de yol gosterici olmaktadirlar. Ailesel Akdeniz Atesi (AAA), Turkler, Yahudiler, Ermeniler ve Araplar'da daha sik gorulen otozomal resesif kalitilan bir hastaliktir. Calismamizda, AAA konusunda en fazla atif almis ilk 100 makale incelenmistir.
Gerec ve Yontemler: Bu bibliometrik arastirma "Thomson Reuters Web of Science" veri tabaninda yapildi. Tum veriler seceneginden "Web of Science[TM] Core Collection" secildi. Temel aramada (basic search) "Title" secilerek, "Familial Mediterranean Fever" kullanilarak ve more settings'te "Science Citation Index Expanded (SCI-E)" kabul edilerek yayinlar Nisan 2016 tarihinde, retrospektif olarak tarandi.
Bulgular: Verilerden elde edilen 2027 makaleden en fazla atif alan ilk 100 makale dahil edildi. En fazla atif alan yazilarin AAA genetigi hakkinda oldugu goruldu. En fazla atif almis ilk 100 yazi icinde; yazarlardan en fazla Livneh'in toplam 1198 atifinin oldugu saptandi. En fazla atif alan yazilar 44 dergide yayinlanmisti. Bu yayinlar ulkelere gore degerlendirildiginde, en fazla atif alan yazilarin birinci sirada israil %37, ikinci %18 ile Turkiye ve ABD ve ucuncu ise %12 ile Fransa'dan yapildigi saptandi.
Sonuc: Bu calisma, AAA konusunda yapilmis en etkili makaleler konusunda bilgi verirken ayni zamanda makalelerin nasil daha fazla atif alacagi konusunda da yol gostermektedir. AAA genetigi en fazla calisilan konu olurken, Israil, Turkiye, ABD ve Fransa bu konuda soz sahibi ulkelerdir.
Anahtar Kelimeler Ailesel Akdeniz Atesi, atif, bibliyometrik analiz
Familial Mediterranean Fever (FMF) is the leading hereditary autoinflammatory disease, influencing more than 100.000 people worldwide (1). The disease is characterised by autosomal recessive pattern of inheritance and episodic, self-limited attacks of fever accompanied by polyserositis (2). Especially, populations living around the Mediterranean region, including Jews, Turks, Arabs and Armenians, are predominantly affected. Because of intercontinental travel in the last century, disease may be seen widespread (3). The mutations, on MEFV gene encoding pyrin protein, are thought to be the cause of FMF. The mutated pyrin interactions in the cell are thought to result in an increased caspase-1 activation and interleukin (IL)-1[beta] processing, leading to an uncontrolled inflammatory state (2). The most important and severe complication, determining morbidity and mortality of FMF, is the development of amyloidosis. Colchicine is still the first-line treatment recommendation for preventing attacks and amyloidosis development (1). Publications are very important for scientific development and they provide a linkage between knowledge production, understanding and usage. Assessment of a publication about a specific subject is determination of the productivity which is an important marker of scientific development. Citation is the reference of a publication by another scientific article. Citations have been used for the assessment of a scientific publication at national, international, institutional and personal areas (4). The most influential publications are likely to be cited much more (5). Studies investigating cumulative scientific data about a specific subject and assessing scientific publication performance are named as bibliometric analysis. Bibliometric studies help researchers monitor the literature data closely, compare the scientific performance of institutions, identify important points of research focus and guide them to design new studies (6). FMF patients with similar genotype may express different phenotypes. Environmental variance is thought to be the contributing factor of this difference (1). In the light of these data, appropriate diagnosis methodology, treatment modalities or preventive approach for FMF may vary between countries. This bibliometric study will reveal the tendency of countries to FMF diagnosis, treatment and follow-up. In this study, we aimed to evaluate the 100 most cited and influential publications about FMF. To the best of our knowledge, this is the first study evaluating FMF by using bibliometric analysis methodology.
Materials and Methods
This study was performed retrospectively by using "Thomson Reuters Web of Science" database in April 2016. This database was known as one of the extensive source providing bibliographical data on medical disciplines (7). It has a wide scope of medical articles, internal consistency and variable filtering options. With the "Web of science[TM] Core Collection" selection and using the search term "FMF", the dataset was composed. The dataset was filtered to include the manuscripts only in the scope of "Science Citation Index Expanded (SCI-E)". The Thomson Reuters Web of Science search returned a total of 2027 publications. These publications were filtered by using "sort by" option as selecting "Times Cites -highest to lowest". The first 100 most cited publications were included in the study. The obtained dataset was then analyzed in terms of topic, abstract, journal, author, country, year and institution. In multicenter studies; the first author's name and institution was taken into account. The subjects of the most cited first 100 manuscripts were revised by reading their titles and abstracts, individually. Additionally, individual and five-year impact factor (both for the year 2016) for each journal publishing these manuscripts were recorded.
The database search returned 2027 manuscripts and the most cited first 100 papers were included. We did not filter our research by using the option "time-older to recent". Also, we did not exclude self-citations. We have just focused on the most cited first 100 manuscript. The number of total citations ranged between 776 for Aksentijevich et al. (8) and 54 for Rabinovitch et al. (Table 1) (9). The oldest publication among these selected most influential manuscripts was by Zemer et al. (10) from Israel and published in 1986. When these publications were ranked according to the first authors; Livneh had 7 manuscripts, Gershoni-Baruch had 4 manuscripts and Ben-Cherit, Tunca, Chae, Toutiou, Booth and Ozen each had 3 manuscripts (Table 1). All the remaining authors had only one publication. Additionally, Livneh had the highest volume of total citations with 1198. This was followed by Ben-Chetrit with 534 citations, Tunca with 464 citations, Toutiou with 413 citations, Chae with 406 citations, Gershoni-Baruch with 317 citations, Booth with 255 citations, and Ozen with 209 citations (Table 1). When these authors who had the highest number of publications were assessed according to their countries; 3 authors were from Israel, 2 were from Turkey and the remaining authors were from the United States, France and United Kingdom. These most cited manuscripts were published in 44 journals. Seven journals among these most cited journals had an impact factor above 10 with a 4.017 median. "New England Journal of Medicine" had the highest impact factor (45.941) and "Cell" (28.779) and "Nature Genetics" (24.416) were the following high-impact journals (Table 2). When these journals were evaluated according to the number of total citations; "Arthritis and Rheumatism" had the most citations (1337) and "European Journal of Human Genetics" (1039) and "Cell" (776) were the following journals. We could not reach the 5-year impact factors of 6 journals from ISI Web of Knowledge database. "Arthritis and Rheumatism", "European Journal of Human Genetics" and "Seminars in Arthritis and Rheumatism" were sharing the first place according to the number of publications per journal with nine manuscripts for each. "Journal of Rheumatology" was following with 8 manuscripts and "Lancet" and "American Journal of Medical Genetics" were sharing the third line with four manuscripts per each journal (Table 2). The evaluation of the 100 most-cited articles for the institutes is shown in Table 3. "Tel Aviv University" was the first institute with 16 publications; "Hacettepe University" was the second institute with 10 publications and "Hopital Arnaud de Villeneuve, Biochemical Genetics Laboratory" was the third institute with 8 publications. Also, "Tel Aviv University" was again the first in terms of institute citation numbers with 1937 citations. "NIAMSD, Arthritis and Rheumatism Branch, Bethesda" (n=1859) and Hospital Arnaud de Villeneuve, Biochemical Genetics Laboratory (n=1560) were the following institutes. When citation numbers per manuscripts were assessed, "NIAMSD, Arthritis and Rheumatism Branch, Bethesda" was the leading institute (n=309.8) and "Hopital Arnaud de Villeneuve, Biochemical Genetics Laboratory" (n=195) and "Hadassah University" (n=138) were the following institutes (Table 3). Except two of them (by Chae and Tunca), the most cited 10 manuscripts were older than ten years (Table 4). A limitation of the bibliometric analysis studies is that the older manuscripts may accrue much more citations. To avoid this bias in our study, the total citation numbers were evaluated per years. The study entitled "Ancient missense mutations in a new member of the RoRet gene family are likely to cause FMF" by Aksentijevich et al. (8) from the United States was again the first in terms of this assessment. Additionally, United States, Israel and France each had three, Turkey had only one publication among the first ten most cited manuscripts. Furthermore, five of these 10 most cited manuscripts were about genetics of FMF (Table 4). When these publications were evaluated in terms of countries; Israel had the most cited manuscripts with 37%, Turkey and United States with 18%, France with 12%, United Kingdom with 5%, Italy and Kuwait with 2%, and other countries with 6% (Figure 1). The genetics of FMF was the most widely studied topic (23/100).
There were only four multicenter studies. These studies according to their first author and title were as follows; Aksentijevich et al. (8) "Ancient missense mutations in a new member of the RoRet gene family are likely to cause FMF", Bernot et al. (12) "A candidate gene for FMF", Tunca et al. (14) "FMF in Turkey: results of a nationwide multicenter study" (14), and Touitou et al. (33) "International Study Group for Phenotype-Genotype Correlation in Familial Mediterranean Fever, Country as the primary risk factor for renal amyloidosis in FMF". Two of these manuscripts were published in 1997 and the others were published in 2005 and 2007. One of these manuscripts was about genotype-fenotype correlation; the other was a clinical study. The rest of them were about the genetics of FMF. Additionally, abstracts of 13 studies were not available in Web of Science, thus, these manuscripts could not be stratified (Figure 2).
Figure 1. Proportion of citations by country Israel 37% USA 18% Turkey 18% France 12% England 5% Italy 2% Kuwait 2% Other 6% Note: Table made from pie chart.
The present bibliometric study was conducted to evaluate the most cited first 100 manuscripts in the field of FMF. The most frequent topic covered in these most influential manuscripts was the genetics of FMF, studied well with 23 publications. Israel, Turkey, United States and France were the leading countries contributing to the literature about the genetics of FMF. Although, United States is located outside the Mediterranean region, well studies have been published from these countries. Today, it is known that, FMF may be seen worldwide because of intercontinental travel (3). Intercontinental travel may be the reason of precious manuscripts published from the United States. Furthermore, the amount of financial resources allocated for studies about the genetics of FMF in these countries, seems to be the other contributing factor. The diagnosis of FMF is based on clinical findings such as recurrent fever accompanied by polyserositis (21). Genetic confirmation supports the clinical diagnosis. Homozygote M694V mutation is supposed to be an important risk factor for the development of amyloidosis (3,11,44). The results of our study indicate that FMF genetics has been studied more than clinical trials. Although clinical findings are enough for the diagnosis, the genetics of FMF seems to be much more interesting for researchers. There are only a few multicenter studies among these most cited first 100 manuscripts (8,12,14,33). Multicenter studies, which will be conducted between all Mediterranean countries, may have more scientific value and should be encouraged. The first circumstance of worldwide scientific development is to publish manuscripts which will have numerous citations (6). The share for scientific studies allocated from the budgets of economically strong countries is much more than the other countries. This makes the manuscripts of these countries to be published in respectable journals and cited more. By this way, economically developed countries are also taking place at the top of the scientifically developed countries (106). In our study, we evaluated the contributing countries in terms of World Bank data. While Israel, United States and France were taking place in high income (>12.736 $) countries, Turkey was in upper-middle income (4126-12.736 $) status (107). Impact factor consisting of the citations of the manuscripts by the scientific community and influential manuscripts tend to receive more citations. Hence, the high-impact journals are believed to be higher quality and publish more influential manuscripts. In this study, journals with higher impact factors were (New England Journal of Medicine, Cell, Nature Genetics, Lancet, Annals of Internal Medicine) consisting only the 11% of all publications in the first 100 manuscripts. Additionally, the median impact factor was 4.017 and 53% of all manuscripts were published in journals with an impact factor under 5. The status of the manuscripts although published in low-impact journals but received many citations, tells us that the journal should not be evaluated only by its impact factor; the citation numbers should be considered also. When these 100 most cited manuscripts were ranked according to their first authors; Livneh was the first and Gershoni-Baruch, Tunca, Ben-Cherit, Ozen, Touitou, and Boot were the following most contributing authors. This author rank is strikingly correlated with the prevalence of FMF in those countries. Livneh and Gershoni-Baruch were from Israel and Ozen and Tunca were from Turkey. Accordingly, the prevalence of the disease in non-Ashkenazi Jews was between 1/256 and 1/500, and was 1/1073 in the Turkish population (3,11,24). Consequently, much more manuscripts have been published from the countries where FMF was more prevalent. Tel Aviv University, Hacettepe University, Hopital Arnaud de Villeneuve, Biochemical Genetics Laboratory, NIAMSD and Arthritis and Rheumatism Branch, Bethesda were the institutions with the greatest number of publications in the top 100. We already know that the manuscript number is positively correlated with the disease prevalence. Besides this, we also know that developed countries with well equipped laboratories may be arbiter, especially about the genetic disorders. The main limitation of this type of bibliometric studies is different kind of defaults affecting the statistical results. Disproportionate citations which may arise from institutional bias, self citation, language bias or personal bias are some of those defaults. Additionally, we observed that older publications may receive more citations. To control this citation bias, the number of citations per year was calculated. This citation rate was used to rank the first 10 authors. Furthermore, we used only "Thomson Reuters Web of Science" database in our study. Although it has a wide scope of medical articles, it would be better to use more than one database. Additionally, we assume that evaluation of multicenter studies according to their first authors, is insufficient.
This work provides the most influential manuscripts related to FMF and serves as a guide to what makes a paper citable. "The genetics of FMF" was the most widely studied topic and Israel, Turkey, United States and France were revealed as the arbiter countries of FMF topic. In this study, we tried to attract attention to the less studied topics about FMF. Additionally, we revealed that older publications can receive more citations. Besides this, we also revealed that, developed countries with well equipped laboratories have arbiter publications about the genetics of FMF although the disease is not prevalent in their countries.
Ethics Committee Approval: Retrospective study.
Informed Consent: Retrospective study.
Peer review: Externally and internally peer-reviewed.
Surgical and Medical Practices: D.Y., H.B.U., Concept: D.Y., H.B.U., Design: D.Y., H.B.U., Data Collection or Processing: D.Y., H.B.U., Analysis or Interpretation: D.Y., H.B.U., Literature Search: D.Y., H.B.U., Writing: D.Y., H.B.U.
Conflict of Interest: No conflict of interest was declared by the authors.
Financial Disclosure: The authors declared that this study received no financial support.
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(75.) Eisenberg S, Aksentijevich I, Deng Z, Kastner DL, Matzner Y. Diagnosis of familial Mediterranean fever by a molecular genetics method. Ann Intern Med 1998; 129: 539-42.
(76.) Chae JJ, Wood G, Richard K, Jaffe H, Colburn NT, Masters SL, et al. The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment. Blood 2008; 112: 1794-803.
(77.) Schwartz T, Langevitz P, Zemer D, Gazit E, Pras M, Livneh A. Behcet's disease in Familial Mediterranean fever: characterization of the association between the two diseases. Semin Arthritis Rheum 2000; 29: 286-95.
(78.) Livneh A, Zemer D, Siegal B, Laor A, Sohar E, Pras M. Colchicine prevents kidney transplant amyloidosis in familial Mediterranean fever. Nephron 1992; 60: 418-22.
(79.) Marek-Yagel D, Berkun Y, Padeh S, Abu A, Reznik-Wolf H, Livneh A, et al. Clinical disease among patients heterozygous for familial Mediterranean fever. Arthritis Rheum 2009; 60: 1862-6.
(80.) Ozen S, Bakkaloglu A, Yilmaz E, Duzova A, Balci B, Topaloglu R, et al. Mutations in the gene for familial Mediterranean fever: do they predispose to inflammation? J Rheumatol 2003; 30: 2014-8.
(81.) Roldan R, Ruiz AM, Miranda MD, Collantes E. Anakinra: new therapeutic approach in children with Familial Mediterranean Fever resistant to colchicine. Joint Bone Spine 2008; 75: 504-5.
(82.) Flatau E, Kohn D, Schiller D, Lurie M, Levy E. Schonlein-Henoch syndrome in patients with familial Mediterranean fever. Arthritis Rheum 1982; 25: 42-7.
(83.) Gershoni-Baruch R, Brik R, Shinawi M, Livneh A. The differential contribution of MEFV mutant alleles to the clinical profile of familial Mediterranean fever. Eur J Hum Genet 2002; 10: 145-9.
(84.) Livneh A, Aksentijevich I, Langevitz P, Torosyan Y, G-Shoham N, Shinar Y, et al. A single mutated MEFV allele in Israeli patients suffering from familial Mediterranean fever and Behcet's disease (FMF-BD). Eur J Hum Genet 2001; 9: 191-6.
(85.) Yalcinkaya F, Ozen S, Ozcakar ZB, Aktay N, Cakar N, Duzova A, et al. A new set of criteria for the diagnosis of familial Mediterranean fever in childhood. Rheumatology (Oxford) 2009; 48: 395-8.
(86.) Schattner A, Lachmi M, Livneh A, Pras M, Hahn T. Tumor necrosis factor in familial Mediterranean fever. Am J Med 1991; 90: 434-8.
(87.) Duzova A, Bakkaloglu A, Besbas N, Topaloglu R, Ozen S, Ozaltin F, et al. Role of A-SAA in monitoring subclinical inflammation and in colchicine dosage in familial Mediterranean fever. Clin Exp Rheumatol 2003; 21: 509-14.
(88.) Kiraz S, Ertenli I, Arici M, Calguneri M, Haznedaroglu I, Celik I, et al. Effects of colchicine on inflammatory cytokines and selectins in familial Mediterranean fever. Clin Exp Rheumatol 1998; 16: 721-4.
(89.) Holdcroft A, Smith M, Jacklin A, Hodgson H, Smith B, Newton M, et al. Pain relief with oral cannabinoids in familial Mediterranean fever. Anaesthesia 1997; 52: 483-6.
(90.) Aisen PS, Haines KA, Given W, Abramson SB, Pras M, Serhan C, et al. Circulating hydroxy fatty acids in familial Mediterranean fever. Proc Natl Acad Sci USA. 1985; 82: 1232-6.
(91.) Belkhir R, Moulonguet-Doleris L, Hachulla E, Prinseau J, Baglin A, Hanslik T. Treatment of familial Mediterranean fever with anakinra. Ann Intern Med 2007; 146: 825-6.
(92.) Ozen S, Ben-Chetrit E, Bakkaloglu A, Gur H, Tinaztepe K, Calguneri M, et al. Polyarteritis nodosa in patients with Familial Mediterranean Fever (FMF): a concomitant disease or a feature of FMF? Semin Arthritis Rheum 2001; 30: 281-7.
(93.) Tunca M, Tankurt E, Akbaylar Akpinar H, Akar S, Hizli N, Gonen O. The efficacy of interferon alpha on colchicine-resistant familial Mediterranean fever attacks: a pilot study. Br J Rheumatol 1997; 36: 1005-8.
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Dilek Yilmaz (1), Hilal Bektas Uysal (2)
(1)Adnan Menderes University Faculty of Medicine, Department of Paediatrics, Division of Paediatric Nephrology, Aydin, Turkey
(2)Adnan Menderes University Faculty of Medicine, Department of Internal Medicine, Aydin, Turkey
Address for Correspondence/Yazisma Adresi:
Dilek Yilmaz MD, Adnan Menderes University Faculty of Medicine, Department of Paediatrics, Division of Paediatric Nephrology, Aydin, Turkey Phone : +90 505 595 43 69 E-mail : firstname.lastname@example.org ORCID ID: orcid.org/0000-0001-8630-6032
Received/Gelis Tarihi : 14.11.2016
Accepted/Kabul Tarihi : 02.12.2016
Table 1. The top 100 cited paper in Familial Mediterranean Fever Rank First author Total Rank citations 1 Aksentijevich I. (8) 776 51 2 Livneh A. (11) 653 52 3 Bernot A. (12) 559 53 4 Zemer D. (10) 444 54 5 Ben-Chetrit E. (13) 367 55 6 Tunca M. (14) 292 56 7 Chae JJ. (15) 252 57 8 Mege JL. (16) 247 58 9 Centola M. (17) 242 59 10 Touitou I. (18) 238 60 11 Samuels J. (19) 230 61 12 Shoham NG. (20) 209 62 13 Aksentijevich I. (21) 204 63 14 Pras E. (22) 198 64 15 Cazeneuve C. (23) 176 65 16 Yilmaz E. (24) 157 66 17 Bernot A. (25) 156 67 18 Onen F. (1) 147 68 19 Papin S. (26) 145 69 20 Lachmann HJ. (27) 139 70 21 Shohat M. (28) 137 71 22 Dewalle M. (29) 133 72 23 Livneh A. (30) 130 73 24 Zemer D. (31) 126 74 25 Cazeneuve C. (32) 123 75 26 Touitou I. (33) 117 76 27 Pras M. (34) 113 77 28 Tunca M. (35) 112 78 29 Pras E. (36) 111 79 30 Ozdogan H. (37) 107 80 31 Livneh A. (38) 107 81 32 Barakat MH. (39) 107 82 33 Yalcinkaya F. (40) 104 83 34 Rogers DB. (41) 102 84 35 Dowds TA. (42) 99 85 36 Stoffman N. (43) 99 86 37 Saatci U. (44) 99 87 38 Booth DR. (45) 98 88 39 Mansfield E. (46) 96 89 40 Ben-Chetrit E. (47) 95 90 41 Lidar M. (48) 92 91 42 Livneh A. (49) 92 92 43 Gershoni-Baruch R. (50) 91 93 44 Gershoni-Baruch R. (51) 90 94 45 Korkmaz C. (52) 90 95 46 Matzner Y. (53) 90 96 47 Shinar Y. (54) 88 97 48 Chae JJ. (55) 86 98 49 Livneh A. (56) 86 99 50 Booth DR. (57) 84 100 Rank First author Total citations 1 Ozen S. (58) 83 2 Gang N. (59) 82 3 Meyerhoff J. (60) 81 4 Samuels J. (61) 80 5 Langevitz P. (62) 80 6 Pras M. (63) 79 7 Daniels M. (64) 78 8 Booty MG. (65) 77 9 Kallinich T. (66) 77 10 Lidar M. (67) 73 11 Gershoni-Baruch R. (68) 73 12 Booth DR (69) 73 13 Ben-Chetrit E. (70) 72 14 Meinzer U. (71) 71 15 Calligaris L. (72) 71 16 El-Shanti H. (73) 71 17 Dode C. (74) 70 18 Eisenberg S. (75) 69 19 Chae JJ. (76) 68 20 Schwartz T. (77) 67 21 Livneh A. (78) 67 22 Marek-Yagel D. (79) 66 23 Ozen S. (80) 66 24 Roldan R. (81) 64 25 Flatau E. (82) 64 26 Gershoni-Baruch R. (83) 63 27 Livneh A. (84) 63 28 Yalcinkaya F. (85) 62 29 Schattner A. (86) 62 30 Duzova A. (87) 61 31 Kiraz S. (88) 61 32 Holdcroft A. (89) 61 33 Aisen PS. (90) 61 34 Belkhir R. (91) 60 35 Ozen S. (92) 60 36 Tunca M. (93) 60 37 Garcia-Gonzalez A. (94) 59 38 La Regina M. (95) 58 39 Touitou I. (96) 58 40 Barakat MH. (97) 58 41 Moser C. (98) 57 42 Mor A. (99) 57 43 Brik R. (100) 57 44 Topaloglu R. (101) 56 45 Bakkaloglu A. (3) 55 46 Padeh S. (102) 55 47 Langevitz P. (103) 55 48 Baykal Y. (104) 54 49 Majeed HA. (105) 54 50 Rabinovitch O. (9) 54 Table 2. Journals with the top 100 cited Familial Mediterranean Fever Journal title Impact Five year factor impact 2016 factor 1. American Journal of Human Genetics 11.092 11.711 2. American Journal of Medical Genetics - - 3. American Journal of Medicine 4.907 4.910 4. American Journal of Reproductive Immunology 2.130 1.964 5. Amyloid-International Journal of Experimental and 1.677 1.701 Clinical Investigation 6. Anaesthesia 2.315 2.124 7. Annals of Internal Medicine 15.516 14.913 8. Annals of the Rheumatic Diseases 6.411 5.915 9. Arthritis Care&Research - - 10. Arthritis and Rheumatism 7.677 7.417 11. Best Practice&Research in Clinical Rheumatology 2.088 2.368 12. Biochemical and Biophysical Research Communications 2.749 2.802 13. Blood 10.896 9.768 14. British Journal of Haematology 4.490 3.733 15. Cell 29.887 28.779 16. Cell Death and Differentiation 8.254 8.168 17. Clinical and Experimental Rheumatology 2.270 2.226 18. Clinical Rheumatology 1.644 1.571 19. Current Opinion in Rheumatology 4.299 4.114 20. European Journal of Human Genetics 4.003 3.365 21. European Journal of Pediatrics 1.277 1.440 22. Human Molecular Genetics 7.806 7.724 23. Johns Hopkins Medical Journal - - 24. Joint Bone Spine 1.659 1.520 25. Journal of Pediatrics 4.017 4.220 26. Journal of Rheumatology 3.151 3.225 27. Lancet 28.638 24.201 28. Medicine 4.721 6.417 29. Nature Genetics 25.556 24.416 30. Nephrology Dialysis Transplantation 3.167 3.097 31. Nephron - - 32. Netherlands Journal of Medicine 1.548 1.226 33. New England Journal of Medicine 52.589 45.941 34. Pediatrics 4.473 5.056 35. Pediatric Nephrology 1.936 1.878 36. Proceedings of the National Academy of Sciences of 9.598 10.369 the United States of America 37. QJM-AN International Journal of Medicine 2.863 3.261 38. QJM-Monthly Journal of the Association of Physicians - - 39. Quarterly Journal of Medicine 2.495 2.623 40. Rheumatology International 1.270 1.417 41. Rheumatology 4.045 4.271 42. Scandinavian Journal of Rheumatology 2.640 2.401 43. Seminars in Arthritis and Rheumatism 3.681 4.017 44. British Journal of Rheumatology - - Journal title Number of Number of manuscripts total in the top 100 citations 1. American Journal of Human Genetics 3 503 2. American Journal of Medical Genetics 4 361 3. American Journal of Medicine 1 62 4. American Journal of Reproductive Immunology 1 54 5. Amyloid-International Journal of Experimental and 1 130 Clinical Investigation 6. Anaesthesia 1 61 7. Annals of Internal Medicine 2 129 8. Annals of the Rheumatic Diseases 2 146 9. Arthritis Care&Research 1 72 10. Arthritis and Rheumatism 9 1337 11. Best Practice&Research in Clinical Rheumatology 1 92 12. Biochemical and Biophysical Research Communications 1 99 13. Blood 3 406 14. British Journal of Haematology 1 86 15. Cell 1 776 16. Cell Death and Differentiation 1 145 17. Clinical and Experimental Rheumatology 2 122 18. Clinical Rheumatology 1 54 19. Current Opinion in Rheumatology 1 80 20. European Journal of Human Genetics 9 1039 21. European Journal of Pediatrics 2 170 22. Human Molecular Genetics 1 156 23. Johns Hopkins Medical Journal 1 113 24. Joint Bone Spine 1 64 25. Journal of Pediatrics 1 73 26. Journal of Rheumatology 8 753 27. Lancet 4 608 28. Medicine 3 603 29. Nature Genetics 1 559 30. Nephrology Dialysis Transplantation 1 57 31. Nephron 1 67 32. Netherlands Journal of Medicine 1 92 33. New England Journal of Medicine 3 732 34. Pediatrics 2 134 35. Pediatric Nephrology 1 55 36. Proceedings of the National Academy of Sciences of 3 522 the United States of America 37. QJM-AN International Journal of Medicine 2 171 38. QJM-Monthly Journal of the Association of Physicians 2 134 39. Quarterly Journal of Medicine 1 107 40. Rheumatology International 1 147 41. Rheumatology 3 305 42. Scandinavian Journal of Rheumatology 1 79 43. Seminars in Arthritis and Rheumatism 9 644 44. British Journal of Rheumatology 1 60 Table 3. Institutions with the highest number of papers in the top 100 Institution Number of Total Citations publication number of per in top 100 citations publication Tel Aviv University 16 1937 121 Hacettepe University 10 752 75.2 Hop Arnaud De Villeneuve, Biochim Genet Lab 8 1560 195 NIAMSD, Arthrit and Rheumatism Branch, Bethesda 6 1859 309.8 Hadassah University 5 693 138 Genet and Genom Branch, Bethesda 5 579 115.8 Dokuz Eylul University 4 611 152 Rambam Med Ctr, Insritue Human Generic 4 317 79.2 Heller Insritue Med 2 570 285 UCL Royal Free and University College 2 237 118.5 Istanbul University 2 197 98.5 Ankara University 2 166 83 Fac Med Safat 2 165 82.5 Institutes with one publication 32 2638 82.4 Table 4. Top 10 papers with the highest citation rate Rank Citation First Senior Title rate per author author year 1 38.8 Aksentijevich I. Doggett NA. Ancient missense mutations in a new member of the RoRet gene family are likely to cause FMF 2 32.6 Livneh A. Pras M. Criteria for the diagnosis of FMF 3 28 Bernot A. Grateau G. A candidate gene for FMF 4 24.3 Tunca M. Cobankara V. FMF (FMF) in Turkey - Results of a nationwide multicenter study 5 22.9 Chae JJ. Kastner DL. The B30.2 domain of pyrin, the FMF protein, interacts directly with caspase-1 to modulate IL-1 beta production 6 19.3 Ben-Chetrit E. Levy M. FMF 7 14.8 Touitou I. Touitou I. The spectrum of FMF mutations 8 14.3 Zemer D. Gafni J. Colchicine in the prevention and treatment of the amyloidosis of FMF 9 14.2 Centola M. Kastner DL. The gene for Familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators 10 10.2 Mege JL. Capo C. Overproduction of monocyte-derived tumor-necrosis-factor -alpha, IL-6, IL-8 and increased neutrophil superoxide generation in behcets-disease - a comparative -study with FMF and healthy-subjects Rank Date Institution Country 1 1997 NIAMSD, Arthrit and USA Rheumatism Branch, Bethesda 2 1997 Tel Aviv University Israel 3 1997 Hop Arnaud De France Villeneuve, Biochim Genet Lab 4 2005 Dokuz Eylul University Turkey 5 2006 Genet&Genom Branch, USA Bethesda 6 1998 Hadassah University Israel Hosp 7 2001 Hop Arnaud De France Villeneuve, Biochim Genet Lab 8 1986 Heller Institue Med Res Israel 9 2000 NIAMSD, USA Arthrit&Rheumatism Branch 10 1993 Hop St Marguerite, France Immunol Lab IL: Interleukin, FMF: Familial Mediterranean Fever
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|Title Annotation:||Original Article / Ozgun Arastirma|
|Author:||Yilmaz, Dilek; Uysal, Hilal Bektas|
|Publication:||Meandros Medical and Dental Journal|
|Date:||Aug 1, 2017|
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