Printer Friendly

BerGenBio ASA and Merck & Co. partner for phase II combination lung cancer trials.

M2 PHARMA-March 9, 2017-BerGenBio ASA and Merck & Co. partner for phase II combination lung cancer trials

(C)2017 M2 COMMUNICATIONS

Norwegian BerGenBio ASA announced on Wednesday that it has formed a partnership with Merck & Co. (NYSE: MRK) (known as MSD outside the US and Canada) and will conduct Phase II combination studies of its oral Axl kinase blocker BGB324 alongside Merck's PD-1 inhibitor KEYTRUDA (pembrolizumab) in patients with advanced non-small cell lung cancer (NSCLC) and triple-negative breast cancer (TNBC).

The compound Axl kinase was chosen as it promotes cancer cell migration, epithelial-mesenchymal transition (EMT), tumour cell proliferation and therapy resistance, according to European Biotechnology, which said that the the protein is overexpressed in the membranes of 60% of lung cancers, highly invasive breast cancers, and pancreatic cancer as well as in acute myeloid leukemia (AML).

Studies have suggested that this overexpression can result in a resistance to both targeted therapies and conventional chemotherapy in different models, including lung cancer, breast cancer resistant to EGFR inhibition, oesophageal carcinoma, gastrointestinal stromal tumours and AML.

BerGenBio will conduct two international Phase II studies to evaluate the potential clinical synergy of combining BGB324 with Merck's anti-PD-1 therapy.

((Comments on this story may be sent to info@m2.com))

COPYRIGHT 2017 Normans Media Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2017 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:M2 Pharma
Date:Mar 9, 2017
Words:204
Previous Article:CooperGenomics Receives ISO 15189 Accreditation in United Kingdom Laboratories for Noninvasive Prenatal Testing.
Next Article:Cambridge University launches new initiative to support 'world-leading industry-academia collaborations' in therapeutics.
Topics:

Terms of use | Privacy policy | Copyright © 2020 Farlex, Inc. | Feedback | For webmasters