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Benefits of child-to-parent kidney donation justify risks.

Child-to-parent (CTP) kidney transplantation offers advantages over cadaveric transplants that justify the risks to the donor, according to researchers at the Medical College of Wisconsin in Milwaukee.

Eric Cohen, MD and colleagues used UNOS data to assess the impact of donor source on kidney transplantation outcomes. The study included 3,797 CTP transplants, 8,284 other living donor transplants, and 44,792 cadaveric transplants. Logistic regression analysis showed that CTP transplantation provided significantly lower rates of graft failure and death at 1 year than did cadaveric transplantation, with additional analysis indicating that these benefits extended beyond the first year.

For CTP donors, the 1 in 3,000 mortality risk is equivalent to about 65 years of lost life, the investigators reported. But CTP recipients are estimated to gain about 5,500 patient years of survival over recipients of cadaveric grafts. All CTP recipients achieve improved survival, but the benefit is smaller in diabetic recipients over age 60.

While the study results showed that CTP outcomes are not better than outcomes with other living donors, "for the 50- to 60-year old patient, an adult son or daughter may be the only living donor option," said Cohen. "Based on the current data, the risk of CTP donation is very small compared to the gain. No longer should we discourage child-to-parent donation."
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Comment:Benefits of child-to-parent kidney donation justify risks.
Publication:Transplant News
Article Type:Brief Article
Geographic Code:1USA
Date:May 26, 2001
Words:219
Previous Article:News from Transplant 2001, The Joint American Transplant Meeting; Chicago, IL, May 12-16 - Racial gap narrowing in kidney transplant outcomes.
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