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Bacterial meningitis.

Ciprofloxacin and ceftriaxone are better than rifampin for prevention of bacterial meningitis in patients at risk of developing the infection, a recent Cochrane Review suggests.

These drugs appear to be as effective as rifampin--the treatment that tends to be used for eradicating Neisseria meningitidis associated with bacterial meningitis--but they are associated with less risk of development of antibiotic resistance, said Abigail Fraser, M.D., of Rabin Medical Centre, Petah-Tikan, Israel, and her colleagues.

Furthermore, ciprofloxacin and ceftriaxone are each given in a single dose, whereas rifampin is given twice daily for 2 days. For this reason, selecting ciprofloxacin or ceftriaxone could improve compliance, the reviewers concluded (Cochrane Database Syst, Rev. 2005 [1]:CD004785.pub2. DOI:10.1002/14651858.CD004785.pub2).
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Title Annotation:CLINICAL CAPSULES
Author:Worcester, Sharon
Publication:Internal Medicine News
Article Type:Brief Article
Geographic Code:1USA
Date:Mar 1, 2005
Words:120
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