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Bacterial decontamination reduces GVHD in patients receiving BMTs, study finds.

Bacterial decontamination with metronidazole and ciprofloxin can significantly reduce the severity of graft-versus-host disease (GVHD) in patients with hematologic malignancies receiving HLA-identical bone marrow transplants (BMT) from sibling donors, according to German researchers.

An open-label, 5-week trial in 134 BMT patients showed that combination treatment with metronidazole and ciprofloxin resulted in "...a pronounced reduction of intestinal anaerobic bacterial growth posttransplant" compared with single-drug ciprofloxin therapy, researchers at the University Hospital of Essen, Germany reported in the May 15th issue of Blood. Moreover, significantly fewer patients receiving combination therapy developed grades II to IV acute GVHD compared with those treated with ciprofloxin alone, with rates of 25% and 50%, respectively.

The benefits of bacterial decontamination were limited to patients receiving HLA-identical BMT from sibling donors, according to Dietrich Beelen, MD, and colleagues.
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Comment:Bacterial decontamination reduces GVHD in patients receiving BMTs, study finds.
Publication:Transplant News
Geographic Code:1USA
Date:Jul 16, 1999
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