Bacterial decontamination reduces GVHD in patients receiving BMTs, study finds.
An open-label, 5-week trial in 134 BMT patients showed that combination treatment with metronidazole and ciprofloxin resulted in "...a pronounced reduction of intestinal anaerobic bacterial growth posttransplant" compared with single-drug ciprofloxin therapy, researchers at the University Hospital of Essen, Germany reported in the May 15th issue of Blood. Moreover, significantly fewer patients receiving combination therapy developed grades II to IV acute GVHD compared with those treated with ciprofloxin alone, with rates of 25% and 50%, respectively.
The benefits of bacterial decontamination were limited to patients receiving HLA-identical BMT from sibling donors, according to Dietrich Beelen, MD, and colleagues.
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|Comment:||Bacterial decontamination reduces GVHD in patients receiving BMTs, study finds.|
|Date:||Jul 16, 1999|
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