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BPD and the broader landscape of neuropsychiatric illness.

Dr. Henry A. Nasrallah's recent Editorial on borderline personality disorder (BPD) (Cu RRENT PsYCIIIATRY, From the Editor, April 2014, p. 19-20,32 [http://bitly/le8yAwE]) describes BPD as a heritable brain disease. I have been arguing this point for many years, often finding support from my colleague, Hagop Akiskal, MD, and opposition from my psychoanalytic colleagues.

In recent papers (1), (2) on brain changes in BPD and the connection between BPD and bipolar disorders, I wrote that there often is a heritable aspect to the condition. There are exceptions to such heritability, as in the setting of a horrific environment (eg, father-daughter incest, parental brutality), where the same symptoms seen in BPD develop primarily from post-natal influences. Dr. Akiskal and I were discussing this a long time back, before MRI. Now I feel vindicated, with generous help from someone of Dr. Nasrallah's prestige and influence.

There also is electrophysiological (including evoked potential) evidence for neural pathology in BPD, as well as data derived from single photon emission CT scanning. The burgeoning literature on MRI and functional MRI studies of BPD is in good agreement about the brain changes most relevant to BPD and that are found with regularity in this condition.

Particularly when BPD is diagnosed in people (usually women) who do not have a history of neglect, sexual molestation, parental humiliation or cruelty, or head injury, what else is there, if not genetically predisposed alterations in the fronto-limbic structures (and maybe the periaqueductal gray) that underlie the so-called "personality disorder," and, not surprisingly, bipolar disorders, especially bipolar II disorder, which often is the other side of the coin as BPD, and amenable to the same combination of medication and psychotherapy?

Michael H. Stone, MD Professor of Clinical Psychiatry Columbia College of Physicians and Surgeons New York, New York

As a psyclliatristipsychoanalyst who works with BPD patients, I read Dr. Nasrallah's April 2014 Editorial with great interest and enthusiasm. Over the past 10 years, I have been impressed with the number of patients with BPD whose nonverbal learning disorders and auditory and visual processing disorders have gone undiagnosed. Recently, I lectured on this topic to the staff of a school for children with a range of neuropsychiatric disorders; the staff found my observations about such comorbidity consistent with their observations. These dysfunctions, or neurological variations--unknown to the parent and the child--interfere with early object-relation formation, attachment capacity, and learning. Neuropsychiatry and psychological development are, in fact, part of the same system.

An example: For 12 years, I have been treating a patient who has auditory processing and working memory problems, meaning that she could not process the connections among different ideas. This difficulty frustrated her parents, who, in their frustration, criticized her for not paying attention. She was labeled "bad" and assumed the role of the "black sheep" in her family. Although she was intelligent, she was often wrong in her judgments and choices, and easily frustrated. In therapy, as I realized what part of her problem was, I changed my technique.

When my patient asked me to tell her the sequence of understandings that we had just put together, I invited her to take my pad and write down her sense of it. As she described each part of that sequence tome, we would discuss it and I would remind her of lost fragments. Gradually, she learned to put ideas together; however, I also watched her struggle to hold these ideas in working memory and to use them.

Over time, she has improved and is more functional. After several years of disability, she returned to work, although she still struggles interpersonally.

With many of such patients, I have had to modify traditional techniques of psychotherapy. I am fascinated by, and enjoy, such intensive psychotherapy. I am also amazed to see the impact of previously unknown neuropathologic variations on development. The more I learn about the impact of neuropsychiatry on psychological development, the more I can help my patients.

Howard Wishnie, MD Cambridge, Massachusetts


(1.) Stone MH. The spectrum of borderline personality disorder: a neurophysiological view. Neuropsychiatric Electrophysiology. In press.

(2.) Stone MN. A new look at borderline personality disorder and related disorders: hyper-activity in the limbic system and lower centers. Psychodyn Psychiatry. 2013;41(3):437-466.

Dr. Nasrallah responds

I appreciate Dr. Stone's kind words and concurrence with my thinking about BPD. It would have been appropriate to include discussion of neurophysiological findings in my Editorial, but I opted to use my limited space to focus on structural and functional neuroimaging and genetics.

Henry A. Nasrallah, MD Professor and Chairman Department of Neurology & Psychiatry Saint Louis University School of Medicine St. Louis, Missouri
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Author:Nasrallah, Henry A.
Publication:Current Psychiatry
Date:Jun 1, 2014
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