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Autogenous Vaccine for Management of Warts in a Heifer.


Bovine Papillomatosis (BP) is a cutaneous contagious disease of cattle occurring in all age groups, manifested in the form of warts/papillomas on the skin caused by Bovine Papilloma Virus (BPV).

Papillomatous growths usually found around the eye, mouth, ears, on the side of neck, jaw, shoulders and on the udder. Infection by bovine Papillomatous virus occurs as a result of multiplication of virus in basal cells leading to warts formation.

Warts are of four common types namely squat, flat, tag and pedunculated. These warts are benign and regress spontaneously. Infection usually results in weight loss, retarded growth and lesions on mammary gland interfere with milking leading to reduction in milk yield. Due to cauliflower like growths on skin, animal's value is also deteriorated thus the disease can lead to serious economic loss if not diagnosed and treated early. Warts may vary in size from pea sized to tennis ball and cauliflower like growth. This in later stages may spread to entire body as numerous nodules or large masses which are either hard or soft to touch.

The present clinical report describes use of autogenous vaccine for management of papillomatosis.

Material and Methods

During June 2016, a two and half year Holstein Friesian crossbred heifer suffering from severe generalized papillomatosis was presented. The animal has multiple papillomoe varying in size from 0.5cm to 3cms in diameter disseminated around the eye, jaws, sides of neck, ears, shoulder and abdomen.

Preparation of Autogenous Vaccine

Older papillomas were selected, minced and suspended in 10 percent Formalin kept overnight. Next day the suspension was filtered through the muslin cloth. The extracts were collected and suspended in normal saline solution and triturated further. The final suspension was again filtered using muslin cloth and Streptopencillin @ 2mg/ml was added to the suspension. The animal was treated with a dose of 10 ml subcutaneously and revaccinated at seven days interval for six weeks.


Autogenous vaccine administration caused sloughing off the warts from the affected areas. Regression started at about tenth day after beginning of treatment and in six weeks all warts disappears and animal shows complete recovery.


Although papillomas are usually benign, its treatment is a challenge to the field Veterinarians. Different treatment methods have been adopted to treat the disease. Surgical intervention may be possible, if less area was involved. Effective medicines for warts are not available. The animal selected for our study had long lasting multiple nodules without showing any signs of regression and treatment with autogenous vaccine showed 97.5 percent efficiency in resolving the warts.


Warts in cattle effectively treated by using autogenous vaccine.


Smith, B.P.(2002). Large Animal Internal Medicine. 3rd Ed., Mosby, Inc. p.1211-12.

Sreeparvathy, M., Harish, C. and Anuraj, K.S.(2011). Autogenous Vaccination as a treatment method for bovine Papillomatosis. J. Livestock Sci. 2: 38-40.

M. Govindharaja Bhaskar (1)

Veterinary Dispensary

Department of Animal Husbandry


Dist. Chittor - 517194 (Andhra Pradesh)

(1.) Veterinary Assistant Surgeon and Corresponding author. E-mail:

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Title Annotation:Short Communication
Author:Bhaskar, M. Govindharaja
Publication:Intas Polivet
Article Type:Report
Date:Jan 1, 2018
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