At risk of losing their home.
Analysis by the homelessness charity Shelter has revealed the region is a hotspot for repossessions.
Shelter has used data produced by the Ministry of Justice based on the number of possession orders issued per 1,000 households across every local authority area.
Lenders issue a possession order when a homeowner is at serious risk of losing their home after defaulting on their agreement.
The research found a "clustering" of private households on Tyneside facing the threat of repossession.
North Tyneside, South Tyneside, Gateshead, County Durham and Sunderland were all identified as "repossession hotspots" due to their position in the top fifth of the national league table.
Sunderland was ranked highest with 425 possession orders, giving the city a rate of 4.81 per 1,000 private households.
Shelter said the research found unemployment had risen at more than double the rate in the identified hotspots when compared to the areas least at risk.
Campbell Robb, chief executive of Shelter, said: "This research paints a frightening picture of repossession hotspots in the North East."