Printer Friendly

AstraZeneca and Merck enter into strategic oncology collaboration.

M2 EQUITYBITES-July 27, 2017-AstraZeneca and Merck enter into strategic oncology collaboration

(C)2017 M2 COMMUNICATIONS http://www.m2.com

AstraZeneca (LON: AZN) and Merck & Co Inc (NYSE: MRK), known as MSD outside of the US and Canada, have entered into a strategic oncology collaboration to co-develop and co-commercialise AstraZeneca's Lynparza (olaparib) for multiple cancer types, the London-based company disclosed on Thursday.

The drug is an innovative, first-in-class oral poly ADP ribose polymerase (PARP) inhibitor. It is currently approved for BRCA-mutated ovarian cancer in multiple lines of treatment. However, there are 14 indications currently being developed across several tumour types, including breast, prostate, and pancreatic cancers. The strategic collaboration is expected to further increase the number of treatment options available to patients.

Under the terms of the agreement, the two companies will work together to develop and commercialise Lynparza, both as a monotherapy and as a combination treatment with other potential medicines. The partners will work independently to develop and commercialise the treatment in combination with their respective PD-L1 and PD-1 medicines, Imfinzi (durvalumab) and Keytruda (pembrolizumab).

The companies will also work together to develop and commercialise AstraZeneca's selumetinib, which is an oral, potent, selective inhibitor of MEK, part of the mitogen-activated protein kinase (MAPK) pathway. This treatment is currently being developed for multiple indications, including thyroid cancer.

The terms of the agreement state that the two companies will share the development and commercialisation costs for Lynparza and selumetinib monotherapy and non-PD-L1/PD-1 combination therapy opportunities. They will fund all development and commercialisation costs of the drugs in combination with their own PD-L1 and PD-1 medicines.

Merck will pay AstraZeneca up to USD8.5bn in total consideration. This will include an upfront payment of USD1.6bn, USD750m for certain licence options, and up to USD6.15bn subject to successful achievement of regulatory and sales milestones.

((Comments on this story may be sent to info@m2.com))

COPYRIGHT 2017 Normans Media Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2017 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:M2 EquityBites (EQB)
Date:Jul 27, 2017
Words:315
Previous Article:Prosperity Bancshares reports stable net income for Q2 2017 year over year.
Next Article:BAI renews collaboration with FinTechStage.
Topics:

Terms of use | Privacy policy | Copyright © 2019 Farlex, Inc. | Feedback | For webmasters