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Aseptic Abscesses and Inflammatory Bowel Disease: Two Cases and Review of Literature.

1. Introduction

Aseptic abscesses (AA) are a rare and serious extraintestinal manifestation (EIM) of inflammatory bowel disease (IBD). Despite having the highest incidence and prevalence of IBD in the world, there are no reports of this entity in Canada [14]. In this study, we describe two local cases and review the literature on AA with underlying IBD.

IBD-associated AA is a rare condition with fewer than 50 cases reported, largely in the European literature [5]. AA are deep abscesses with neutrophilic features associated with negative cultures and serologic tests, failure of antibiotic therapy, and improvement on corticosteroids. Due to the scarcity of reported cases and absence of observational and experimental studies, clinicians face challenges in diagnosing and managing patients. This report evaluates two cases of IBD-associated AA for clinical and investigative findings to add to the sparse Canadian literature.

2. Methods

2.1. Chart Review. This retrospective single center study was approved by our Institutional Review Board with a waiver for informed consent. Our radiology information system (syngo, Siemens Medical Solutions USA, Inc., Malvern, PA) was searched using Montage Search and Analytics (Montage Healthcare Solutions, Philadelphia, PA) for CT examinations performed between January 2005 and July 2016. The terms "splenic abscess," "aseptic abscess," "inflammatory bowel disease," "ulcerative colitis," and "Crohn's disease" were used. The Soarian Clinicals database (Cerner Corporation, Kansas City, MO) was used to find additional clinical data on identified patients. Diagnoses of AA were made based on (1) history of IBD; (2) imaging of focal enclosed lesions with the typical appearance of abscesses; (3) failure of antibiotic therapy; and (4) negative blood and aspirate. Patient charts were analyzed for demographics, symptoms, medical comorbidities, disease diagnosis and progression, and management.

2.2. Literature Review. For the literature review, an electronic search of the online databases MEDLINE, EMBASE, and CINAHL as well as the reference lists of retrieved articles was performed to identify potential articles published in print or online before July 14, 2016. Search terms included "Inflammatory bowel disease", "aseptic splenic abscess", "aseptic abscess", and "extraintestinal". Abstracts of all publications found through the above search strategy were screened for relevancy. Full-text articles, if available, were retrieved. If a translation for a non-English article was not available, authors were contacted for full-text translations. If they did not respond, these articles were excluded from the literature review.

3. Results

3.1. Case Reports. We describe two cases of IBD-associated AA of patients who presented to St. Michael's Hospital in Toronto. The clinical characteristics of our two cases are summarized in Table 1.

3.1.1. Case One. A 33-year-old man with a history of ulcerative colitis (UC) and prior subtotal colectomy and ileal pouch-anal anastomosis (IPAA) presented to hospital with a six-day history of fevers, nonradiating left-upper quadrant abdominal pain worse with movement, a 15 lbs weight loss, and genital skin lesions with the typical appearance of pyoderma gangrenosum. His bowel movements were unchanged from 8-10 nonbloody stools per day. Past medical history was significant for corticosteroid-refractory pancolonic UC managed with subtotal colectomy and IPAA at age 18. Surgical pathology on the colectomy specimen confirmed ulcerative pancolitis. In the subsequent 15 years, he was treated for three episodes of pouchitis where each responded well to three weeks of ciprofloxacin and metronidazole

On presentation, laboratory testing showed an elevated white blood cell (WBC) count of 18.0 x [10.sup.3] cells/[micro]L with a neutrophil count of 16.4 x [10.sup.3] cells/[micro]L, C-reactive protein (CRP) of 114.9 mg/L, and erythrocyte sedimentation rate (ESR) of 51mm/hr. An abdominal CT scan revealed multiple mostly confluent hypodense lesions in the spleen, the largest being 7.0 x 3.2 x 5.2 cm (Figure 1(a)), concerning for abscesses. Aspiration of the largest abscess revealed pus. The abscesses were drained and he was started on ceftriaxone and metronidazole.

The patient failed to improve. Cultures of blood and the aspirate remained sterile even after 7-day incubation. All antibiotics were then stopped. Pouchoscopy revealed inflammation in the IPAA with no inflammation in the pouch or proximal small bowel. A repeat abdominal CT scan showed progression of the splenic lesions. The patient was started on IV corticosteroids. His abdominal pain, fevers, and genital skin lesions improved and he was discharged home on a tapering course of oral steroids and rectal aminosalicylates. He was admitted one year later with a one-month history of left-sided flank pain, sweats, fevers, and abdominal pain with no change in bowel habits or weight loss. An abdominal and pelvic CT scan showed multiple focal ill-defined hypoattenuating lesions scattered throughout the spleen with the largest measuring 4.2 cm indiameter. Aspiration of an abscess proved sterile. Pouchoscopy showed active inflammation.

The patient was commenced on IV steroids and transitioned to an oral tapered dose of prednisone. Additionally, he was initiated on 5 mg/kg of infliximab every eight weeks, increased to 10 mg/kg due to lack of response. His abdominal pain and fever ceased and a repeat abdominal CT scan six months later revealed resolution of the multiple splenic abscesses (Figure 1(b)).

3.1.2. Case Two. A 27-year-old woman presented to hospital with fever, abdominal pain, chest pain, and weight loss. Past medical history was of UC diagnosed at age 26, treated with prednisone and azathioprine, for which she was nonadherent and ceased therapy. At the time of presentation, she described four days of left-upper quadrant abdominal pain and pleuritic chest pain radiating to her left shoulder. There was fever, oral ulcers, a 10 lbs weight loss, and arthritis of the hands, elbows, knees, and ankles. She had an elevated WBC count (21.1 x [10.sup.3] cells/[micro]L), neutrophil count (16.0 x [10.sup.3] cells/[micro]L), CRP (112mg/L), and ESR (88mm/hr). Abdominal CT scans revealed an enlarging heterogeneous abscess measuring 3.7 x 4.0 x 2.4 cm initially and 4.2 x 3.6 x 2.6 cm 3 days later (Figure 2).

Aspiration of the splenic collections revealed pus. Cultures of blood and aspirate were negative. The patient declined further endoscopic staging of her UC. She underwent splenectomy and the resected spleen contained multiple aseptic abscesses. Histology revealed areas of neutrophildominant necrotic tissue.

The patient presented two months later with fever, arthralgia, oral ulcers, and tender papules on her buttocks, arms, and legs. Biopsy of the lesions revealed neutrophilic dermatosis (ND). Based on her clinical and histological findings, she was diagnosed with Sweet's syndrome and started on prednisone 60 mg PO daily. Her dermatologic and rheumatologic symptoms rapidly resolved. She was initiated and remains on infliximab 5 mg/kg every six weeks, continuing to do well on this regimen.

3.2. Literature Review of Aseptic Abscess in Inflammatory Bowel Disease. A total of 37 cases of IBD-associated AA were found in our literature search of MEDLINE, EMBASE, and CINAHL and through hand-searching. These articles were published from 1994 [6] to 2016 [20, 21]. The clinical characteristics of these cases can be found in Table 1. Of the 37 total patients, approximately 65% (n = 24) were female and 35% (n = 13) were male. The mean ages of patients with AA and IBD at the time of diagnosis were 28.9 years (range 10-80 years) and 26.1 years (range 12-72 years), respectively.

IBD preceded the diagnosis of AA in 48.6% of patients (n = 18), was concomitant in 24.3% (n = 9), and appeared subsequently in 27.0% (n = 10). With respect to IBD type, 73.0% of patients had underlying CD (n = 27), 24.3% (n = 9) had UC, and 2.7% (n = 1) had indeterminate colitis. During their diagnosis of AA, 45.9% patients (n = 17) had an IBD flare, while 54.1% (n = 20) did not. Regarding initial symptoms, 83.8% of patients presented with fever (n = 31), 67.6% with abdominal pain (n = 25), 32.4% with diarrhea (n = 12), and 32.4% with weight loss (n = 12). The most common AA locations were the spleen (n = 23) and liver (n = 5), with 32.4% of patients found to have lymph node involvement (n = 12). 10.8% of patients had ND (n = 4).

Regarding treatment, 91.9% of patients received antibiotics (n = 34), to which they were all unresponsive. Conversely, 94.6% received and responded to corticosteroid therapy (n = 35). 40.5% of patients (n = 15) received additional immunosuppressive therapy of azathioprine (n = 12), cyclophosphamide (n = 3), methotrexate (n = 1), infliximab (n = 2), and adalimumab (n = 1). Additionally, 37.8% of patients underwent splenectomy (n = 14), 13.5% had incision and drainage of abscesses (n = 5), and 5.4% had lymph node excision (n = 2). Relapses were reported in 54.1% of patients (n = 20), with the average number of relapses among all 37 cases being 1.22 (range: 0-5). The implementation (or absence) of maintenance therapy was reported in 45.9% of cases (n = 17), with 47.1% of these patients placed on maintenance therapy (n = 8/17), including low-dose prednisone (n = 3), azathioprine (n = 4), sulfasalazine (n = 3), and adalimumab (n = 1). Among the patients receiving maintenance therapy, 5 relapses occurred while on prednisone maintenance therapy. Alternatively, no relapses occurred while patients were on azathioprine, sulfasalazine, or adalimumab.

4. Discussion

We present two cases of aseptic abscesses, a rare EIM of IBD. Our patients were aged 33 and 27 years old, respectively, and both had underlying UC. Both patients presented with fever, abdominal pain, and weight loss and had splenic lesions which proved sterile. Patient 1 did not respond to antibiotics, improved on corticosteroids, and was maintained with infliximab. Patient 2 received a splenectomy and subsequently was maintained with infliximab.

4.1. Clinical Diagnosis. There are no accepted guidelines for the diagnosis of AA. However, Andre and colleagues created a set of common characteristics based on a case series with literature review: (1) deep abscesses with neutrophilic features; (2) negative serologic tests for bacteria and fungi and cultures of blood and aspirate; (3) when administered, failure of broad-spectrum antibiotic therapy including antituberculosis therapy; (4) rapid clinical improvement on corticosteroid therapy with or without additional immunosuppressant therapy and subsequent radiologic evidence of abscess resolution [5]. Our patients were assessed using this definition of AA, with patient 1 meeting all criteria and patient 2 meeting all but the fourth criterion (i.e., corticosteroid therapy), as corticosteroids were not attempted on this patient. Additionally, when applying these criteria to patients from the literature, we found multiple reports of superficial AA in IBD. Sterile abscesses were reported on the upper eyelids, scalp, face, chest, forearm, and nasal septum [8, 10, 11, 13, 18]. These findings may warrant expansion of criterion 1 to include superficial AA.

4.2. Pathology. There is some ambiguity on how to best describe sterile lesions with underlying IBD. Superficial lesions have been described as neutrophil-dominant with surrounding granulomatous tissue [10, 11, 13]. Similarly, in our report, aspiration of patient 2's splenic abscess revealed areas of neutrophil-dominant necrosis. Lesions in previously published cases have also been described as rheumatoid nodules, though this assertion has been debated [12,22]. With this lack of consensus in mind, the most accurate term to describe these lesions is "aseptic abscess" [5].

AA shares a similar pathological picture with ND, showing polymorphonuclear leukocyte infiltrates and sterile abscesses [23-25]. Both of our patients had ND: patient 1 developed pyoderma gangrenosum, and patient 2 developed Sweet's syndrome. In the literature, 10.8% of patients had ND (n = 4). Sweet's syndrome and pyoderma gangrenosum are recognized complications of IBD, though it is unclear if their incidence is higher in IBD patients with AA compared to those without AA [23, 25].

4.3. Association with Inflammatory Bowel Disease. AA has been documented as an EIM found before, during, and after the diagnosis of IBD [5]. Our patients had established IBD diagnoses before any clinical symptoms of AA appeared. Other cases in our institution may not have been found through the database search if the AA preceded IBD and thus was not classified as an EIM. This may indicate a need to perform colonoscopy on patients with AA and no underlying IBD, as 51.3% of published cases reported IBD diagnoses concomitant with or following AA diagnoses (n = 19).

With regard to types of IBD, both of our patients had UC compared to only 24.3% (n = 9) of patients reported in the literature. A recent case report by Boschetti et al. of AA described a diagnosis of multiple systemic abscess syndrome, though they called this a complication of CD and not IBD, removing patients with UC from consideration [21]. Despite the higher incidence of CD, compared to UC-associated AA, it is important for clinicians to realize that AA can be an EIM regardless of the type of underlying IBD.

The association between disease severity of IBD and the manifestation of AA is unclear. Among included studies, only one reported clinical or endoscopic measures of disease activity for IBD, such as the Crohn's Disease Activity Index (CDAI) or the Crohn's Disease Endoscopic Index of Severity (CDEIS) [11, 26, 27]. Though inflammatory biomarkers such as CRP and ESR were commonly presented, they cannot be used as surrogates IBD activity, as AA is an inflammatory process itself.

4.4. Treatment. AA has been treated with corticosteroid therapy, azathioprine, cyclophosphamide, methotrexate, infliximab, adalimumab, incision and drainage, and splenectomy. From the literature and from our own institution, there were 36 of 39 patients that received and responded to corticosteroid therapy, which indicates its effectiveness as the first-line for induction. Maintenance therapy should follow because relapse is common, as seen in over half of the patients in the literature review and in one of our two patients. Interestingly, no patients in the literature experienced relapse while on maintenance therapy of azathioprine, sulfasalazine, adalimumab, or infliximab, although the durability of this response is unknown [7, 8, 10, 13, 17, 19, 21]. There were no reported fatal outcomes.

5. Conclusions

The cases described in this study are the first to be reported in Canada. They highlight the importance of recognizing IBD-associated AA in at-risk patients. The lack of diagnostic guidelines can lead clinicians to forego potentially effective corticosteroid and immunosuppressant therapy in favour of surgical intervention, as in our patient 2 who received a splenectomy. Future research should be aimed towards rigorous multicentre prospective case-control studies with greater participant numbers to better understand the natural history of this condition, to form the foundation for diagnostic criteria and to help improve recognition, reporting, and management.

Abbreviations
AA:    Aseptic abscesses
EIM:   Extraintestinal manifestation
IBD:   Inflammatory bowel disease
CD:    Crohn's disease
UC:    Ulcerative colitis
IC:    Indeterminate colitis
IV:    Intravenous
WBC:   White blood cell
ND:    Neutrophilic dermatoses.


http://dx.doi.org/10.1155/2017/5124354

Competing Interests

The authors declare that they have no competing interests.

Authors' Contributions

Natasha Bollegala, Jenna Tessolini, Ahmed Al-Mazroui, Michael A. Scaffidi, and Samir C. Grover were responsible of study conception and design. Adrienne Showler, Natasha Bollegala, Ahmed Al-Mazroui, Rishad Khan, Jenna Tessolini, and Errol Colak were responsible of acquisition of data. Rishad Khan, Errol Colak, and Samir C. Grover were responsible of analysis and interpretation of data. Natasha Bollegala, Rishad Khan, Ahmed Al-Mazroui, and Samir C. Grover were responsible of drafting of the manuscript. Natasha Bollegala, Ahmed Al-Mazroui, Michael A. Scaffidi, Jenna Tessolini, Rishad Khan, Adrienne Showier, and Samir C. Grover were responsible of critical revision of the manuscript for important intellectual content. Natasha Bollegala, Rishad Khan, Michael A. Scaffidi, Ahmed Al-Mazroui, and Samir C. Grover assisted in writing of the manuscript. Errol Colak and Samir C. Grover were responsible of administrative, technical, or material support. Samir C. Grover was responsible of study supervision. Natasha Bollegala, Jenna Tessolini, Ahmed Al-Mazroui, Michael A. Scaffidi, Rishad Khan, Adrienne Showler, Errol Colak, and Samir C. Grover approved the final manuscript.

References

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[27] J. Y. Mary and R. Modigliani, "Development and validation of an endoscopic index of the severity for Crohn's disease: A Prospective Multicentre Study. Groupe d'Etudes Therapeutiques des Affections Inflammatoires du Tube Digestif (GETAID)," Gut, vol. 30, no. 7, pp. 983-989, 1989.

Natasha Bollegala, (1) Rishad Khan, (2) Michael A. Scaffidi, (2) Ahmed Al- Mazroui, (2) Jenna Tessolini, (2) Adrienne Showler, (3) Errol Colak, (4) and Samir C. Grover (2)

(1) Division of Gastroenterology, Womens College Hospital, Toronto, ON, Canada

(2) Division of Gastroenterology, St. Michael's Hospital, Toronto, ON, Canada

(3) Division of Infectious Disease, St. Michael's Hospital, Toronto, ON, Canada

(4) Department of Medical Imaging, St. Michael's Hospital, Toronto, ON, Canada

Correspondence should be addressed to Samir C. Grover; samir.grover@utoronto.ca

Received 18 August 2016; Revised 22 December 2016; Accepted 22 January 2017; Published 6 February 2017

Academic Editor: Helmut Neumann

Caption: Figure 1: Axial contrast enhanced CT images demonstrating (a) multiple splenic abscess (thick arrows) with (b) resolution and residual scarring (thin arrow) following treatment with steroids.

Caption: Figure 2: Axial contrast enhanced CT image demonstrating a heterogeneous splenic abscess (thick arrow).
Table 1: Summary of IBD associated AA cases from the
literature database and our search at St. Michael's Hospital.

Study/patient ID      Age/sex        IBD phenotype
                                      (CD/UC/IC)

Andre et al.         Mean 24.4      17CD, 3UC, 1IC
2007 [5]*/1-21    (range 10/54)/
                    12 F & 9 M

Lamport et al.         38/F               CD
[6]/22

Act is et al.          30/M               CD
[7]/23

Tirpitz et al.         80/F               UC
[8]/24

Murata et al.          18/F               UC
[9]/25

Hara et al.            39/M               UC
[10]/26

Coat et al.            31/F               CD
[11]/27

Kinjo et al.           34/F               UC
[12]/28

Holstein et al.        26/M               CD
[13]/29

Li et al. [14]/        39/F               UC
30

Coyne [15]/31          34/M               CD

Renna et al.           20/F               CD
[16]/32

Zakout et al.          29/F               CD
[17]/33

Yilmaz et al.          34/F               UC
[18]/34

Brooks and             19/F               CD
Ghatfari [19]/
35

Sakharpe et al.        48/F               CD
[20]/36

Boschetti et           40/F               CD
al. [21]/37

Bollegala et           33/M               UC
al./case 1

Bollegala et           27/F               UC
al./case 2

Study/patient ID       Age of IBD         IBD flare
                   diagnosis/temporal     during AA
                      relation to
                    diagnosis of AA

Andre et al.       Average age of IBD    Yes (n = 8),
2007 [5]*/1-21    onset = 23.7 (range    no (n = 13)
                   12-38)/before (n =
                  7), concomitant (n =
                   7), after (n = 7)

Lamport et al.         34/before              No
[6]/22

Act is et al.           30/after             Yes
[7]/23

Tirpitz et al.         72/before             Yes
[8]/24

Murata et al.          15/before              No
[9]/25

Hara et al.            34/before              No
[10]/26

Coat et al.            28/before             Yes
[11]/27

Kinjo et al.           31/before             Yes
[12]/28

Holstein et al.        24/before              No
[13]/29

Li et al. [14]/        26/before             Yes
30

Coyne [15]/31          33/before              No

Renna et al.         20/concomitant          Yes
[16]/32

Zakout et al.        29/concomitant          Yes
[17]/33

Yilmaz et al.          22/before             Yes
[18]/34

Brooks and           19/concomitant          Yes
Ghatfari [19]/
35

Sakharpe et al.      Unknown/before           No
[20]/36

Boschetti et         Unknown/after            No
al. [21]/37

Bollegala et           18/before             Yes
al./case 1

Bollegala et           26/before              No
al./case 2

Study/patient ID        Symptoms            Location of AA

                                         Spleen alone (n = 6)
Andre et al.        Fever (n = 19),      or spleen and lymph
2007 [5]*/1-21    abdominal pain (n =       nodes (n = 4);
                  17), weight loss (n    pharynx and cervical
                  = 10), diarrhea (n=      muscles (n = 1);
                           5)            liver (n = 1); liver
                                         and lymph nodes (n =
                                         3); kidney (n = 1),
                                           and lymph nodes
                                            alone (n = 4)

Lamport et al.        Leg weakness         Bilateral psoas
[6]/22                                   muscle and epidural

Act is et al.       Fever, diarrhea,      Spleen, abdominal
[7]/23               abdominal pain          lymph nodes

Tirpitz et al.      Abdominal pain,       Bi-temporal upper
[8]/24            abdominal swelling,          eyelids
                    bloody diarrhea

Murata et al.            Fever                 Sternum
[9]/25

Hara et al.          Painful facial        SC scalp, face,
[10]/26             lesions, fever,      right inner canthus,
                   nonbloody diarrhea      submaxilla, and
                                                chest

Coat et al.         Fever, back pain            Spleen
[11]/27

Kinjo et al.      Fever, bloody stool         SC sternum
[12]/28

Holstein et al.     Fever, diarrhea,        Liver, spleen
[13]/29               weight loss,
                   weakness, loss of
                       appetite

Li et al. [14]/      Fever, bloody         SC left forearm
30                diarrhea, abdominal
                          pain

Coyne [15]/31        Abdominal pain             Spleen

Renna et al.        Fever, abdominal            Spleen
[16]/32             pain, nonbloody
                    diarrhea, weight
                          loss

Zakout et al.      Fever, abdominical           Liver
[17]/33           pain, pain in right
                   shoulder radiating
                  from abdomen, right
                    pleuritic chest
                    pain, nonbloody
                        diarrhea

Yilmaz et al.      Fever, nasal ache,        Nasal septum
[18]/34             difficulty with
                       breathing

Brooks and           Abdominal pain             Spleen
Ghatfari [19]/
35

Sakharpe et al.     Fever, weakness,            Liver
[20]/36            loss of appetite,
                  coughing, chest pain

Boschetti et        Fever, abdominal       Spleen, pancreas
al. [21]/37               pain

Bollegala et        Abdominal pain,             Spleen
al./case 1        fever, weight loss,
                         sweat

Bollegala et        Abdominal pain,             Spleen
al./case 2        chest pain radiating
                   to left shoulder,
                   fever, weight loss

Study/patient ID     Other IBD EIM       Antibiotic     Corticosteroids
                                          treatment

Andre et al.        Arthritis (x4),      Yes (n = 21)    Yes (n = 21)
2007 [5]*/1-21      myalgia (x5), ND
                  (x2), aphthous ulcer
                          (x7)

Lamport et al.             --                Yes              Yes
[6]/22

Act is et al.        Panniculitis,           Yes              Yes
[7]/23               polyneuropathy

Tirpitz et al.    Pyoderma gangrenosum       Yes              Yes
[8]/24

Murata et al.          Arthritis             Yes              Yes
[9]/25

Hara et al.            Arthritis             Yes              Yes
[10]/26

Coat et al.                --                Yes              Yes
[11]/27

Kinjo et al.           Arthritis              No              Yes
[12]/28

Holstein et al.         HLA B27              Yes              Yes
[13]/29              sacroiliitis,
                       Arthritis

Li et al. [14]/        Arthritis             Yes              Yes
30

Coyne [15]/31              --                 No              No

Renna et al.               --                Yes              Yes
[16]/32

Zakout et al.              --                Yes              No
[17]/33

Yilmaz et al.              --                Yes              Yes
[18]/34

Brooks and           Pustular skin           Yes              Yes
Ghatfari [19]/          lesions
35

Sakharpe et al.            --                 No              Yes
[20]/36

Boschetti et        Sweets syndrome          Yes              Yes
al. [21]/37

Bollegala et      Pyoderma gangrenosum       Yes              Yes
al./case 1

Bollegala et        Sweets syndrome,          No              No
al./case 2            oral ulcers,
                       arthritis

Study/patient ID      Additional        Surgical procedures
                     immunotherapy

Andre et al.        Total (n = 10),        Splenectomy
2007 [5]*/1-21    cyclophosphamide (n         (n = 9)
                  = 3), azathioprine
                       (n = 7),
                   methotrexate (n =
                  1), infliximab (n =
                          2)

Lamport et al.            --                    --
[6]/22

Act is et al.        Azathioprine         Splenectomy and
[7]/23                                  lymph node excision

Tirpitz et al.            --                    --
[8]/24

Murata et al.             --                    I&D
[9]/25

Hara et al.               --                    I&D
[10]/26

Coat et al.          Azathioprine           Splenectomy
[11]/27

Kinjo et al.              --                    I&D
[12]/28

Holstein et al.      Azathioprine           Splenectomy
[13]/29

Li et al. [14]/           --                    I&D
30

Coyne [15]/31             --                Splenectomy

Renna et al.              --                Splenectomy
[16]/32

Zakout et al.        Azathioprine               --
[17]/33

Yilmaz et al.             --                    I&D
[18]/34

Brooks and           Azathioprine               --
Ghatfari [19]/
35

Sakharpe et al.           --                    --
[20]/36                                    Laparoscopic

Boschetti et          Adalimumab        biopsy of mesenteric
al. [21]/37                                 lymph nodes

Bollegala et          Infliximab                --
al./case 1

Bollegala et          Infliximab            Splenectomy
al./case 2

Study/patient ID  Maintenance therapy   Number of relapses
                  after diagnosis of
                          AA

Andre et al.        Information not        Mean = 1.38
2007 [5]*/1-21         provided             (n = 12).
                                            range 0-5

Lamport et al.            --                    1
[6]/22

Act is et al.     Prednisone (stopped           4
[7]/23            after 4th relapse),
                  azathioprine (after
                     last relapse)

Tirpitz et al.        Prednisone,               0
[8]/24               sulfasalazine

Murata et al.             --                    4
[9]/25

Hara et al.       Sulfasalazine (after          1
[10]/26                relapse)

Coat et al.               --                    1
[11]/27

Kinjo et al.              --                    1
[12]/28

Holstein et al.   Azathioprine (after           3
[13]/29              3rd relapse)

Li et al. [14]/           --                    0
30

Coyne [15]/31             --                    0

Renna et al.       during, and after            1
[16]/32

Zakout et al.        Azathioprine,              0
[17]/33              sulfasalazine

Yilmaz et al.             --                    0
[18]/34

Brooks and           Azathioprine               0
Ghatfari [19]/
35

Sakharpe et al.           --                    0
[20]/36

Boschetti et          Adalimumab                0
al. [21]/37

Bollegala et      Prednisone & 5-ASA            1
al./case 1         (before relapse),
                   infliximab (after
                       relapse)

Bollegala et          Infliximab                0
al./case 2

AA = aseptic abscess, CD = Crohns disease, EIM = extraintestinal
manifestation, F = female, IC = indeterminate colitis, IBD =
inflammatory bowel disease, I&D = incision and drainage, M = male,
ND = neutrophilic dermatosis, SC = subcutaneo us, UC = ulcerative
colitis. * Case series summary data available.
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Author:Bollegala, Natasha; Khan, Rishad; Scaffidi, Michael A.; Al-Mazroui, Ahmed; Tessolini, Jenna; Showler
Publication:Canadian Journal of Gastroenterology and Hepatology
Article Type:Report
Date:Jan 1, 2017
Words:4924
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