Asahi Glass Company Ltd (Tokyo, Japan) has patented a secretion
signal gene having a base sequence encoding a polypeptide functional as
a secretion signal in fission yeast Schizosaccharomyces pombe
(hereinafter referred to as S. pombe), an expression vector having the
gene and a foreign protein structural gene, a multicloning vector for
construction of the expression vector which has the secretion signal
gene, and efficient secretory production of the foreign protein
structural gene product by S. pombe and the like. (US 5919654)