Printer Friendly

Aromatase inhibitors may hasten bone loss in osteopenia.

WASHINGTON -- Aromatase inhibitors are associated with small but significant levels of additional bone loss in osteopenic women who take the drugs for hormone-sensitive breast cancer, according to a study of 104 women.

After just 1 year of aromatase inhibitor therapy, these women lost a mean of 1.5% in bone mineral density (BMD) at the lumbar spine and 2% at the femoral neck; two of the subjects progressed from osteopenia to osteoporosis, Dr. Pamela Taxel reported in a poster session at an international symposium sponsored by the National Osteoporosis Foundation.

Expected bone loss associated with natural progression generally would be about 0.5%-1% per year, according to Dr. Taxel of the University of Connecticut Health Center, Farmington.

She and her colleagues performed a chart review of 104 women who were taking the drugs for breast cancer and were evaluated for bone health. Of these, 61 (58%) had osteopenia. The patients' mean age was 58 years; they had been on aromatase inhibitor therapy for up to 2 years. At baseline, 18% (11 patients) were taking a bisphosphonate. They were followed for an additional year.

Lumbar spine BMD measurements were available at baseline and at 1 year for 39 women. After 1 year, the women had lost a mean of 1.5% in BMD at this site; 18 women had lost more than 3%. Baseline and 1-year femoral neck BMD measurements were available for 36 women.

After 1 year, there was a mean BMD decrease of 2% at this site. Four women lost more than 3% at the spine and more than 5% at the femoral neck.

Two of the 36 women with both lumbar spine and femoral neck data progressed to osteoporosis during the follow-up period.

The progression in bone loss occurred despite increased patient compliance with vitamin D supplements. At baseline, 74% of the women were taking at least 1,000 mg/day of vitamin D, although 41% were still deficient. At the end of the follow-up period, vitamin D intake had significantly increased, with only 25% of the women still deficient, Dr. Taxel noted.
COPYRIGHT 2009 International Medical News Group
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2009 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:WOMEN'S HEALTH
Author:Sullivan, Michele G.
Publication:Internal Medicine News
Geographic Code:1USA
Date:Jun 1, 2009
Previous Article:NCCN offers updated breast cancer guidelines: genetic counseling is now advised for women with DCIS and a high risk for hereditary breast cancer.
Next Article:No CV benefit from rosuvastatin in dialysis.

Related Articles
Aromatase inhibitors for breast Ca: new concerns. (Musculoskeletal Problems).
Tamoxifen alone discouraged as adjuvant Tx.
Initial versus sequential adjuvant aromatase inhibitor therapy: a review of the current data.
Cost-utility of adjuvant hormone therapies with aromatase inhibitors in postmenopausal women with breast cancer: upfront anastrozole, sequential...
Watch for poor bone health after breast cancer.
Prospective study to assess short-term intra-articular and tenosynovial changes in the aromatase inhibitor-associated arthralgia syndrome.

Terms of use | Privacy policy | Copyright © 2020 Farlex, Inc. | Feedback | For webmasters