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Are the American society for radiation oncology guidelines accurate predictors of recurrence in early stage breast cancer patients treated with balloon-based brachytherapy?

1. Introduction

The concept of treating the entire breast with radiation after breast conserving surgery for breast cancer arose from early data demonstrating a high incidence of invasive or in situ carcinoma remote from the primary tumor in mastectomy specimens [1, 2]. However, clinical data evaluating patterns of recurrence have demonstrated that patients treated with lumpectomy alone have a low rate of recurrences at remote sites, so-called "elsewhere" recurrences. In fact, less than 5% of recurrences in unirradiated patients occur in a quadrant away from the primary tumor and the addition of whole breast irradiation (WBI) has not been shown to reduce the rates of these "elsewhere" failures [3]. Based on documented patterns of breast tumor recurrence after breast conserving surgery, accelerated partial breast irradiation (APBI) emerged as an alternative to WBI [4, 5]. However, data from randomized controlled trials comparing the safety and efficacy of APBI with standard WBI will not be available for several years [6].

In response to the growing interest in APBI, the American Society for Radiation Oncology (ASTRO) Health Services Research Committee convened a Task Force to help guide patient selection for APBI use outside of a clinical trial. In July 2009, the Task Force published a consensus statement (CS) that classified patients as "suitable," "cautionary," and "unsuitable" based on patient and tumor characteristics [7]. It is noteworthy that CS groupings were constructed largely without the use of long-term clinical data on the efficacy of APBI and may not be ideal in identifying appropriate patients for this modality [7].

Few large series have evaluated patient outcomes with APBI based on ASTROCS guidelines and less so with APBI using solely balloon-based brachytherapy techniques [8-10]. This study reviews our single institution-experience with balloon-based APBI in patients with early stage breast cancer and evaluates recurrence rates based on ASTRO CS groupings.

2. Materials and Methods

Following approval by our institutional review board, we performed a retrospective chart review of patients treated with APBI at our institution between March 2004 and May 2010. We identified 238 patients with 243 early stage breast cancers of which 2 had bilateral breast cancer and 3 had metachronous contralateral breast cancers. All patients underwent breast conserving surgery performed by one of two surgeons followed by APBI via balloon catheter brachytherapy. Patients were classified as "suitable," "cautionary," or "unsuitable" based on ASTRO CS guidelines (Table 1).

All clinicopathologic factors were used to assign consensus panel groups, except for BRCA status as information regarding genetic testing was not readily available on most patients. A patient was considered estrogen receptor (ER) positive if the breast tumor contained at least 1% ER positive cells [11]. ER status was unknown for one patient due to a technical error during immunohistochemical staining. She was placed into the "cautionary" group based on tumor histology (invasive lobular carcinoma) and was included in the analysis. Data regarding lymphovascular invasion (LVI) was available for all patients but assessed as indeterminate by the pathologist in 17 of the 243 cancers (7%). These patients were placed into their respective ASTRO categories based on their other clinicopathologic features. Patients with any one "cautionary" or "unsuitable" criterion were placed in that respective category.

Two hundred nine cancers (86.0%) were treated with MammoSite single lumen catheters, 12 (4.9%) with MammoSite multilumen catheters, and 1 (0.4%) with a MammoSite ellipsoidal catheter (Hologic Inc., Bedford, MA). Twenty-one cancers (8.6%) were treated with Contura multilumen catheters (SenoRx Inc., Irvine, CA).

2.1. Catheter Insertion Technique. One hundred thirty of the 243 balloons (53.5%) were placed percutaneously in the office via a lateral incision or an incision at inframammary fold. One hundred thirteen (46.5%) balloons were placed in the operating room, 61 (54.0%) were placed via an open technique, and 52 (46.0%) were placed percutaneously. All of the balloons placed in the operating room we replace data separate operation from the initial lumpectomy. All patients had preplacement ultrasound confirming adequate skin-to-seroma distance [greater than or equal to] 7 mm.

2.2. Radiation Treatment. Our accelerated radiation treatment technique has been previously described in detail [12]. Each patient was seen by radiation oncology for computed tomography-based 3D treatment planning within 48 hours of balloon placement. Patients received 34 Gy delivered 1 cm from the balloon surface, in two fractions of 3.4 Gy each per day, 6 hours apart over 5 treatment days.

2.3. Outcome Measure. Ipsilateral breast tumor recurrence (IBTR) was defined as recurrence of the cancer in the treated breast. Each recurrence was classified by the investigator as either a true recurrence (occurring within 2 cm of the lumpectomy bed) or an elsewhere recurrence, based on the criteria by Recht et al. [13].

2.4. Statistical Analysis. Kaplan-Meier curves were used to generate time-to-event curves for IBTR. Statistical significance of differences between groups was calculated using log rank tests (for Kaplan-Meier curves). Predictions of IBTR over time for individual clinical and pathologic factors were obtained with Cox proportional Hazards Models, which provided a hazard ratio and 95% confidence interval. When one of the groups had no events (such as LVI), the Cox model could not be used and a comparison with the Fisher exact test was instead used to obtain a P value.

3. Results

Of the 243 breast cancers, 58 (24%) were classified as "suitable," 119 (49%) as "cautionary," and 66 (27%) as "unsuitable" per the ASTRO guidelines. Table 2 describes the breakdown of the study cohort according to CS groupings. Lymph node status and extensive intraductal component (EIC) are reported only for patients with invasive carcinoma (n = 72 "cautionary," n=50 "unsuitable"). The 119 cancers in the "cautionary" group met 182 "cautionary" criteria, with 50 (42%) meeting more than one "cautionary" criterion. The majority of "cautionary" patients had either close margins (27%) or DCIS < 3 cm (27%). ER negative tumors comprised 31 (26%) of the "cautionary" cases (invasive, n = 22; DCIS, n=9)and 10 (15%) of the "unsuitable" cases (invasive, n = 6; DCIS, n = 4). Of the 66 cancers in the "unsuitable" group, 11 (17%) met more than one "unsuitable" criterion for a total of 77 criteria. Patients under the age of 50 or with positive margins comprised 73% of the "unsuitable" cases.

3.1. Ipsilateral Breast Tumor Recurrences. The median follow-up was 3.2 (range, 0.2-7.1) years. There were 8 IBTR (3.2%) at a median of 2.9 years, of which one was a true local recurrence and 7 were elsewhere recurrences. The 4-year actuarial IBTR rate for the entire cohort was 5.1% (Figure 1(a)). There were no significant differences in the 4year actuarial IBTR rates between the "suitable," "cautionary," and "unsuitable" categories (0%, 7.2%, and 4.3% resp., P = 0.28)(Figure 1(b)). Three (4.8%) of the 63 patients with DCIS developed an IBTR (1 local, 2 elsewhere). The 4-year rate of IBTR was not different between patients with DCIS and invasive carcinoma (4.3% versus 5.4%, P = 0.51). There were 3 IBTR among 28 patients with ER negative invasive cancers versus 2 of 151 ER positive (crude rate 10.7% versus 1.3%, resp.,). Patients with ER negative invasive cancers had a significantly higher 4-year actuarial IBTR rate compared with ER positive patients (16.5% versus 1.9%, P = 0.03).

Of the 8 IBTR, 3(37.5%) occurred in patients with ER negative invasive tumors (2 triple negative, 1 ER negative/HER2/neu positive). All 3 ER negative recurrences were elsewhere recurrences, which is similar to the percentage of elsewhere recurrences (4 of 5) in the remainder of the cohort (100% versus 80%, P = 0.6). On univariate analysis, patients with ER negative invasive tumors had a higher risk of IBTR, although this did not reach statistical significance (HR = 5.87, P = 0.053). Patients with close/positive margins appeared to be associated with a higher risk of IBTR (HR 7.63, P = 0.02); however only one of the IBTR was a true local recurrence which occurred in a young patient (age 50-59) with DCIS [less than or equal to] 3 cm and negative surgical margins at initial surgery. Age, tumor size, histology, multifocality, LVI, and nodal status were not associated with IBTR (Table 3).

Table 4 shows the tumor characteristics and surgical management of the patients experiencing an IBTR. Five (62.5%) of the 8 IBTR were treated with repeat breast conservation with 2 patients agreeing to additional radiation therapy (1 WBI, 1 APBI). Three of the 8 IBTR, or 1.2% of the entire cohort, were treated with salvage mastectomy. After their in breast recurrences, four patients underwent genetic testing at the discretion of the treating physician. One was found to carry a deleterious mutation in the BRCA1 gene.

3.2. Regional and Distant Recurrences. There were 5 (2.1%) regional recurrences, all axillary, at a median disease free interval of 2.2 years. One was initially classified as "cautionary" and 4 were "unsuitable." Two had concomitant distant metastases at the time of regional recurrence. There were two additional isolated distant metastases. Of the 4 distant metastases, all were originally classified as "unsuitable" and occurred at a median of 1.9 years. Among the 28 ER negative patients, the crude rate of regional and distant recurrence was 7.1% and 3.6%, respectively.

4. Discussion

Data from a recently published Medicare claims database demonstrated an increase in APBI use in women diagnosed with invasive carcinoma from 3.47% in 2003 to 12.52% in 2007 [14]. As a result of the growing popularity of APBI, ASTRO published a CS to provide guidance to physicians and patients regarding the use of APBI outside of a clinical trial. Based on review of the literature and expert opinion, patients considered for APBI were stratified into three major groups: "suitable," "cautionary," and "unsuitable" [7]. It is important to note that the CS groupings were not based on data that identified subsets of patients with higher or lower rates of in breast recurrence with APBI but rather a lack of data supporting its use. Although the ASTRO CS guidelines have been applied to MammoSite Registry data, as well as other single institution series, additional studies are needed to aid in continued refinement of the ASTRO CS groupings [8, 10]. We applied the ASTRO CS groupings to 243 early stage cancers treated with balloon-based brachytherapy at our institution to evaluate recurrence patterns by group. In addition, we evaluated individual clinicopathologic features to identify factors predictive of IBTR in patients treated with balloon-based brachytherapy.

We observed a 4-year actuarial IBTR rate of 5.1% for the entire cohort. Our 4-year recurrence rate is slightly higher than the 3.9% 5-year actuarial rate observed in the MammoSite Registry trial which maybe related to differences in patient and tumor characteristics in each study [15]. When stratified by ASTRO CS groupings, there was no significant difference between the "suitable," "cautionary," and "unsuitable" patient cohorts (0%, 7.2%, and 4.3%, resp., P = 0.28). Our data is consistent with Shaitelman et al. [10] who demonstrated no difference in 5-year IBTR rates for all CS groupings in their 1,025 patients from the MammoSite Registry trial (2.59%, 5.43%, and 5.28%, resp., P= 0.19). In a recent study, Vicini et al. [8]likewisereportedno difference in 10-year rates of IBTR based on ASTRO CS groups (P = 0.86). Similar to our study, Vicini et al. [8] did report a slightly higher (nonsignificant) IBTR rate (7.8%) in "cautionary" patients receiving APBI compared to the other groupings. It is likely that ER negative invasive cancers, as demonstrated by a higher 4-year actuarial IBTR rate of 16.5%, may be driving the observed, albeit nonsignificant higher rate of IBTR among "cautionary" patients in our dataset. Initially, there appeared to be an association between close/positive margins and IBTR. However, since only one of the 8 IBTR was a true recurrence, this finding likely does not reflect a true association between margins and IBTR. Other "cautionary" and "unsuitable" characteristics such as age, tumor size, histology, multifocality, LVI, and nodal status did not seem to affect IBTR. Based on accumulating data, the ASTRO CS groupings as a whole, are poor predictors of patient outcomes. Appropriateness for APBI should be based on individual clinical and pathologic features of the tumor.

Patients with ER negative invasive tumors treated with APBI have been shown to have a higher risk of IBTR in several studies. Data from the MammoSite Registry Trial demonstrated that negative ER status was the only variable, associated with IBTR in patients with invasive carcinoma (OR 4.01, P = 0.003)[10]. Similarly, Wilder et al noted that ER negative tumors treated with APBI had inferior locoregional control, albeit nonsignificant (P = 0.09)and a worse relapse-free survival (P = 0.04)[16]. In our study cohort, patients with ER negative invasive cancers also had a higher rate of IBTR (HR = 5.87), although this did not reach statistical significance (P = 0.053). Given the small total number of ER negative invasive cancers (P = 28), as well as the low absolute number of recurrences in our study, we may be underpowered to demonstrate an association, even if one exists.

Further analysis of our data demonstrated a crude rate of IBTR of 10.7% in our ER negative cohort and 4-year actuarial IBTR rate of 16.5%. Although our crude rate of IBTR appears similar to the 10.1% crude IBTR rate reported by Beitsch et al. [17] in their 139 ER negative MammoSite Registry patients, our rate is higher when taking into account median follow-up time (3.2 years versus 5 years, resp.,). Moreover, the 16.5% 4year rate of IBTR is higher than the 8-year IBTR rate of 13.4% seen in ER negative patients treated with WBI in the absence of adjuvant chemotherapy in the National Surgical Adjuvant Bowel and Breast project (NSABP) B-13 study [18]. The higher IBTR rate among ER negative patients in our study may be explained by the finding of a BRCA mutation in one of the 3 ER negative patients that recurred. Due to the small number of ER negative patients as well as the small number of absolute recurrences, any one relapse will dramatically affect the overall recurrence rate. Excluding this patient would result in a lower crude IBTR rate (7.4%), which is more consistent with the MammoSite Registry data [17]. The recurrence rate is still higher than that of ER positive patients in this study (crude IBTR rate 1.3%) and raises concerns regarding the safety of APBI in this group of patients. Whether these patients would have had a lower IBTR rate with WBI is unknown. Poor tumor biology, rather than inferiority of APBI, may be driving the increased IBTR rate in ER negative patients seen in this and other studies. Until mature data from randomized clinical trials comparing APBI and WBI become available, patients with ER negative invasive tumors should be treated with APBI inside of a clinical trial.

Alternatively, patients with ER positive invasive cancers (n = 151) had a 1.9% 4-year actuarial IBTR rate. The low IBTR rate is consistent with the 1.1% rate of local recurrence seen in ER positive patients treated with WBI in NSABP B-14 at 4 years of followup [19]. Our data support the evidence that patients with ER positive invasive cancers can be safely treated with accelerated partial breast irradiation, with excellent local control.

Our study has several limitations. It is a nonrandomized retrospective review of a modest cohort of patients. Furthermore, the number of patients meeting individual ASTRO criteria is unbalanced because selection for APBI in these patients was at the discretion of the treating physician. Therefore, there are more patients fulfilling certain criteria (ER positive, DCIS, and close margins) and fewer meeting other criteria (ER negative, LVI, and EIC). This, along with a small absolute number of recurrences, may make our study underpowered to demonstrate an association between certain clinical and pathologic factors and risk of IBTR. Following their recurrences, one patient was discovered to carry a deleterious mutation in the BRCA 1 gene. As this patient was not excluded, this may bias our results, resulting in a higher than expected IBTR rate, particularly among ER negative invasive cancers. Finally, our median followup is short. Longer followup is needed to ensure that patients treated with APBI have an acceptably low rate of IBTR.

In conclusion, an analysis of 243 breast cancers treated with balloon-based brachytherapy demonstrated no significant difference in recurrence rates based on ASTRO CS groupings. Patients with ER positive invasive cancers demonstrated low rates of IBTR and can be safely treated with APBI with excellent local control. Conversely, patients with ER negative invasive tumors had a higher rate of IBTR compared with historical controls treated with WBI, which resulted in a higher than expected IBTR for the entire cohort. Although poor tumor biology, rather than inferior disease control with APBI, may be responsible for the worse outcomes, strong consideration should be given in treating patients with ER negative invasive cancers with APBI inside of a clinical trial. Other individual ASTRO criteria were not associated with an increased risk of IBTR. The ASTRO CS groupings are poor predictors of suitability for APBI and decision for treatment should be based on individual clinical and pathologic features.

Conflict of Interests

The authors do not have any financial relationships with Hologic Inc. or SenoRx Inc. They do not have any conflict of interests to disclose.


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Moira K. Christoudias, (1) Abigail E. Collett, (1) Tari S. Stull, (1) Edward J. Gracely, (2) Thomas G. Frazier, (1) and Andrea V. Barrio (1)

(1) Department of Surgery, The Bryn Mawr Hospital, Bryn Mawr, PA 19010, USA

(2) Drexel University College of Medicine, Drexel University, School of Public Health, Philadelphia, PA 19129, USA

Correspondence should be addressed to Andrea V. Barrio;

Received 25 March 2013; Accepted 14 October 2013

Academic Editor: Kazuhiro Yoshida

TABLE 1: American Society for Radiation Oncology (ASTRO) guidelines.

Characteristic                    Suitable

Age, y                  [greater than or equal to] 60
Tumor size, cm            [less than or equal to] 2
Tstage                               T1
Histology                 Invasive ductal or other
                             favorable subtypes
ER status                         Positive
Grade                                Any
Margins               Negative ([greater than or equal
                                  to] 2 mm)
Multifocality, cm         [less than or equal to] 2
Multicentricity                  Unicentric
LVI                                 None
EIC                                 None
Nodal status                      Negative
Nodal surgery                   SLNB or ALND
BRCA 1/2 mutation                Not present
Neoadjuvant therapy              Not allowed

Characteristic           ASTRO CS          Unsuitable

Age, y                     50-59              <50
Tumor size, cm            2.1-3.0              >3
Tstage                    T0 or T2           T3-T4
Histology             Invasive lobular    DCIS > 3 cm
                       or DCIS < 3 cm
ER status                 Negative             NA
Grade                        NA                NA
Margins                 Close (<2mm)        Positive
Multifocality, cm          2.1-3               >3
Multicentricity              NA             Present
LVI                    Limited/focal       Extensive
EIC                    Yes and tumor     Yes and tumor
                         size < 3cm        size > 3cm
Nodal status                 NA             Positive
Nodal surgery                NA          None performed
BRCA 1/2 mutation            NA             Present
Neoadjuvant therapy          NA               Used

CS: consensus statement, DCIS: ductal carcinoma in situ, ER: estrogen
receptor, LVI: lymphovascular invasion, EIC: extensive intraductal
component, SLNB: sentinel lymph node biopsy, and ALND: axillary lymph
node dissection.

TABLE 2: Breakdown of patient cohort by individual clinical and
pathologic characteristics stratified by ASTRO CS grouping.

Characteristic                          ASTRO CS grouping

                                        No. of patients (%)

                                Suitable   Cautionary   Unsuitable
                                 M = 58     N = 119       N = 66
Age, yrs
  [greater than or              58(100)      89(75)       34(52)
    equal to] 60
  50-59                           0(0)       30(25)        4(6)
  <50                             0(0)        0(0)        28(42)
  Unknown (a)                     0(0)        0(0)         0(0)
Tumor Size, cm
  [less than or equal to] 2     58(100)      63(53)       40(61)
  2.1-3.0                         0(0)        9(8)        7(11)
  >3                              0(0)        0(0)         3(4)
  DCIS [less than or equal        0(0)       47(39)       14(21)
    to] 3
  DCIS > 3                        0(0)        0(0)         2(3)
  Unknown (a)                     0(0)        0(0)         0(0)
  IDC                            56(97)      60(51)       45(68)
  ILC                             0(0)        9(8)         5(8)
  DCIS                            0(0)       47(39)       16(24)
  IDC/ILC                         2(3)        2(1)         0(0)
  Adenoid cystic                  0(0)        1(1)         0(0)
  Unknown (a)                     0(0)        0(0)         0(0)
ER status
  Positive                      58(100)      87(73)       56(85)
  Negative                        0(0)       31(26)       10(15)
  Unknown (a)                     0(0)        1(1)         0(0)
  Negative, [greater than or    58(100)      72(61)       21(32)
    equal to] 2mm
  Close, <2mm                     0(0)       47(39)       17(26)
  Positive                        0(0)        0(0)        28(42)
  Unknown (a)                     0(0)        0(0)         0(0)
  None                          58(100)     115(97)       61(92)
  [less than or equal to] 2cm     0(0)        4(3)         3(5)
  2.1cm-3.0cm                     0(0)        0(0)        1(1.5)
  >3cm                            0(0)        0(0)        1(1.5)
  Unknown (a)                     0(0)        0(0)         0(0)
  Unicentric                    58(100)     119(100)     66(100)
  Multicentric                    0(0)        0(0)         0(0)
  Unknown (a)                     0(0)        0(0)         0(0)
  None                           54(93)     107(90)       52(79)
  Limited/focal                   0(0)        7(6)        3(4.5)
  Extensive                       0(0)        0(0)        3(4.5)
  Indeterminate                   4(7)        5(4)        8(12)
  Unknown                         0(0)        0(0)         0(0)
EIC, cm (b)
  None                          58(100)      70(97)       47(94)
  [less than or equal to] 3       0(0)        2(3)         2(4)
  >3                              0(0)       0 (0)         1(2)
  Unknown (a)                     0(0)       0 (0)         0(0)
Nodal status (b)
  Negative                      58(100)     72(100)       39(78)
  Positive                        0(0)        0(0)        7(14)
  None performed                  0(0)        0(0)         4(8)
  Unknown (a)                     0(0)        0(0)         0(0)

CS: consensus statement, DCIS: ductal carcinoma in situ,
IDC: invasive ductal carcinoma, ILC: invasive lobular carcinoma,
ER: estrogen receptor, LVI: lymphovascular invasion, and
EIC: extensive intraductal component.

(a) Patients with tumor characteristics characterized as unknown
or indeterminate were placed in ASTRO categories based on the
other criteria. (b) Excluding DCIS; cautionary N = 72;
unsuitable N = 50.

TABLE 3: Factors associated with ipsilateral breast tumor

Variable                           Hazard ratio        P
                                     (95% CI)

Age: [greater than or equal      0.63 (0.08-5.19)    0.67
  to] 50 versus <50
Age: [greater than or equal      0.55 (0.13-2.32)    0.42
  to] 60 versus <60
Tumor size: >2cm versus          2.20 (0.25-19.75)   0.48
  [less than or equal to]
  2cm (a)
Tumor type: ILC versus other     1.89 (0.23-15.41)   0.55
Tumor type: DCIS versus          1.61 (0.38-6.75)    0.52
  invasive cancer
ER status: negative versus       5.87 (0.97-35.34)   0.053
  positive (a)
Margins: negative versus         7.63 (1.45-40.0)    0.016
Multifocality: yes versus no     2.36 (0.28-19.99)   0.43
LVI: present versus none (a,b)          --           0.60
Nodal status: positive versus           --            1.0
  negative (a,b)

CI: confidence interval, ILC: invasivelobular carcinoma,
DCIS: ductal carcinoma in situ, ER: estrogen receptor, and
LVI: lymphovascular invasion.

(a) Excludes DCIS.

(b) Cox proportional hazards model could not be performed
due to lack of events.

TABLE 4: Surgical management of ipsilateral breast tumor

Case no.   Date of    Time to     Location     ASTRO criteria
           surgery   IBTR (yrs)

22          2005        3.99      Elsewhere     ER negative,
                                                close margin

44          2005        3.13      Elsewhere      ER negative

50          2005        5.83        Local      Age 50-59, DCIS
                                                [less than or
                                               equal to] 3 cm,
                                               and ER negative

71          2006        2.64      Elsewhere    Age < 50, close
                                              margin, and DCIS
                                                [less than or
                                               equal to] 3 cm

91.1 (b)    2007        3.82      Elsewhere     ER negative,
                                                close margin,
                                               and tumor size
                                                 2.1-3.0 cm

107         2006        1.45      Elsewhere   Positive margin,
                                                 2.1-3.0 cm

147         2007        2.73      Elsewhere     Close margin

208         2009        1.21      Elsewhere     Close margin,
                                               age 50-59, and
                                               DCIS [less than
                                              or equal to] 3 cm

Case no.    Surgical    Radiation   Follow-up    Disease
           management    therapy    time (yrs)   status

22         Mastectomy      No          5.21        NED

44         Mastectomy      No          5.33        NED

50         Segmental     No (a)        5.81        NED

71         Mastectomy      No          5.16        DOD

91.1 (b)   Segmental     No (c)        3.95        NED

107        Segmental       Yes         4.52        NED

147        Segmental     Yes (d)       3.50        NED

208        Segmental     No (c)        1.56        NED

ER: estrogen receptor, NED: no evidence of disease, DCIS: ductal
carcinoma in situ, and DOD: dead of disease.

(a) Patient is currently receiving chemotherapy. Decision for
radiation was undetermined at the completion of the study.

(b) Patient tested positive for deleterious mutation in BRCA gene
following recurrence.

(c) Patient declined radiation therapy.

(d) Recurrence treated with APBI via balloon catheter brachytherapy.
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Title Annotation:Clinical Study
Author:Christoudias, Moira K.; Collett, Abigail E.; Stull, Tari S.; Gracely, Edward J.; Frazier, Thomas G.;
Publication:International Journal of Surgical Oncology
Article Type:Report
Date:Jan 1, 2013
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