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Arcus Biosciences signs clinical collaboration with Infinity Pharmaceuticals.

M2 PHARMA-June 28, 2018-Arcus Biosciences signs clinical collaboration with Infinity Pharmaceuticals


United States-based Arcus Biosciences has signed a clinical collaboration with United States-based Infinity Pharmaceuticals.

It was reported yesterday that the collaboration is aimed at evaluating two triple combination therapies in certain tumour types that typically show minimal response to checkpoint inhibition monotherapy. It will assess IPI-549 in combination with AB928, Arcus's dual adenosine receptor antagonist, and AB122, Arcus's anti-PD-1 antibody, and IPI-549 in combination with AB928 and chemotherapy in patients with triple negative breast cancer (TNBC) or ovarian cancer in four separate cohorts.

These four cohorts will be incorporated into Arcus's recently initiated Phase 1/1b trial to evaluate AB928 combinations in TNBC and ovarian cancer. According to the terms of the contract, both parties will share equally expenses related to the four triple-combination cohorts to assess the safety and activity of IPI-549 + AB928 + AB122 and IPI-549 + AB928 + chemotherapy. Each of the four triple-combination cohorts will enrol around 15 patients. Topline data from these studies are expected in 2019.

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Publication:M2 Pharma
Date:Jun 28, 2018
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