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Applications of vibrational spectroscopy in pharmaceutical research and development.


Applications of vibrational spectroscopy in pharmaceutical research and development.

Ed. by Don E. Pivonka et al.

John Wiley & Sons


372 pages




The editors (of AstraZeneca Pharmaceuticals in the US, VS Consulting in the UK, and the U. of Idaho in the US) present 15 chapters that describe applications of infrared and Raman spectroscopy for pharmaceutical discovery and development. In the realm of drug discovery, chapters discuss sampling techniques and fiber-optic probes, application to combinatorial chemistry, determination of structure-activity relationships in molecular bonding, applications of vibrational optical activity in the pharmaceutical industry, and characterization and optimization of chemical synthesis using real-time vibrational spectroscopy. For the topic of drug development, chapters are included on infrared and Raman spectroscopy for process development, analysis of pharmaceutical substances and formulated products by vibrational spectroscopy, Raman analysis of pharmaceuticals, vibrational spectroscopy of solid-state forms (principles and applications), pharmaceutical applications of chemical mapping and imaging, and terahertz spectroscopy for pharmaceutical applications. A concluding chapter discusses history, trends, and prognostications.

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Publication:SciTech Book News
Article Type:Book Review
Date:Mar 1, 2008
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