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Antioxidant supplementation may reduce risk of diabetes.

Antioxidant supplementation significantly reduces oxidative stress while improving insulin sensitivity and decreasing blood levels of chemicals associated with the development of diabetes, according to a new report. (1)

In this randomized, double-blind, controlled trial, 48 overweight and normal-weight young adults received an antioxidant cocktail containing vitamin E (800 IU), vitamin C (500 mg), and beta-carotene (10 mg), or placebo, for eight weeks. Endothelial adhesion molecules, lipid peroxidation, insulin resistance, and adiponectin were assessed at the start of the study and again after eight weeks. At the study's onset, overweight individuals exhibited greater insulin resistance and had higher levels of endothelial adhesion molecules, which have been implicated in the development of diabetes and atherosclerosis. (2)

After eight weeks, the overweight individuals experienced increased insulin sensitivity and decreased levels of endothelial adhesion molecules. Additionally, their oxidative stress decreased, and their levels of adiponectin increased. Higher levels of adiponectin are associated with a reduced risk of both diabetes and cardiovascular disease. (3,4)

Reference

(1.) Vincent HK, Bourguignon CM, Weltman AL, et al. Effects of antioxidant supplementation on insulin sensitivity, endothelial adhesion molecules, and oxidative stress in normal-weight and overweight young adults. Metabolism. 2009 Feb;58(2):254-62.

(2.) Song Y, Manson JE, Tinker L, et al. Circulating levels of endothelial adhesion molecules and risk of diabetes in an ethnically diverse cohort of women. Diabetes. 2007 Jul;56(7):1898-904.

(3.) Chahwala V, Arora R. Cardiovascular manifestations of insulin resistance. Am J Ther. 2008 Dec 23. (4.) Yamauchi T, Kadowaki T. Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases. Int J Obes (Lond). 2008 Dec;32(Suppl 7):S13-8.

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Title Annotation:IN THE NEWS
Author:Kiefer, Dale
Publication:Life Extension
Article Type:Report
Geographic Code:1USA
Date:May 1, 2009
Words:276
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