Printer Friendly

Antihistamine Potent against Chronic Urticaria. (Potency is 50-Fold Higher).

MUNICH - Once-daily desloratadine has roughly a 50-fold greater ability to block histamine-1 as that of other antihistamines, Dr. Rudiger Hein, professor of dermatology at Technical University, Munich, said at a satellite symposium held in conjunction with the 10th Congress of the European Academy of Dermatology and Venereology.

Desloratadine, which has been on the German market for a year, is investigational in the United States. Schering-Plough has filed for marketing approval with the Food and Drug Administration for the indications of chronic idiopathic urticaria and allergic rhinitis.

Also, in vitro studies suggest desloratadine's anti-inflammatory activity is in the same ballpark as that of dexamethasone, said Dr. Martina Kerscher, a dermatologist at the University of Hamburg. In 10 patients with polymorphic light eruption, minimal erythemal dose increased significantly after a single dose of desloratadine. Photosensitivity was further reduced after 5 days of desloratadine at 5 mg/day, she said at the satellite symposium sponsored by Schering-Plough Corp.

Dr. Hein reported on a double-blind trial of 190 patients, aged 12-79 years with chronic idiopathic urticaria, randomly assigned to 5 mg of desloratadine or placebo daily for 6 weeks.

After a single dose of desloratadine, pruritus declined, the number of wheals decreased, sleep disturbance was reduced, and activities of daily living improved. These benefits were maintained throughout the 6-week study No one in the desloratadine group dropped out due to treatment-related adverse events, and there were no clinically significant changes in QT interval or other ECG measurements.

The World Health Organization recently labeled allergic rhinitis as a major chronic respiratory disease. Allergic rhinitis is associated with at least a four- to fivefold increased risk of developing asthma.
COPYRIGHT 2002 International Medical News Group
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2002 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:desloratadine
Author:Jancin, Bruce
Publication:Internal Medicine News
Geographic Code:4EUGE
Date:Jan 1, 2002
Previous Article:Rhinosinusitis Linked to Indoor Air Pollution. (Homes of Patients Studied).
Next Article:The many faces of Statins. (Heart of the Matter).

Related Articles
Zafirlukast plus antihistamine in IgE-receptor-positive hives. (Clinical Rounds: For resistant cases).
Desloratadine improves quality of life in chronic idiopathic urticaria.
Chronic urticaria.
Desloratadine effective for chronic urticaria.
Rupatadine may reduce symptoms of cold urticaria.

Terms of use | Privacy policy | Copyright © 2018 Farlex, Inc. | Feedback | For webmasters