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Antihistamine Potent against Chronic Urticaria. (Potency is 50-Fold Higher).

MUNICH - Once-daily desloratadine has roughly a 50-fold greater ability to block histamine-1 as that of other antihistamines, Dr. Rudiger Hein, professor of dermatology at Technical University, Munich, said at a satellite symposium held in conjunction with the 10th Congress of the European Academy of Dermatology and Venereology.

Desloratadine, which has been on the German market for a year, is investigational in the United States. Schering-Plough has filed for marketing approval with the Food and Drug Administration for the indications of chronic idiopathic urticaria and allergic rhinitis.

Also, in vitro studies suggest desloratadine's anti-inflammatory activity is in the same ballpark as that of dexamethasone, said Dr. Martina Kerscher, a dermatologist at the University of Hamburg. In 10 patients with polymorphic light eruption, minimal erythemal dose increased significantly after a single dose of desloratadine. Photosensitivity was further reduced after 5 days of desloratadine at 5 mg/day, she said at the satellite symposium sponsored by Schering-Plough Corp.

Dr. Hein reported on a double-blind trial of 190 patients, aged 12-79 years with chronic idiopathic urticaria, randomly assigned to 5 mg of desloratadine or placebo daily for 6 weeks.

After a single dose of desloratadine, pruritus declined, the number of wheals decreased, sleep disturbance was reduced, and activities of daily living improved. These benefits were maintained throughout the 6-week study No one in the desloratadine group dropped out due to treatment-related adverse events, and there were no clinically significant changes in QT interval or other ECG measurements.

The World Health Organization recently labeled allergic rhinitis as a major chronic respiratory disease. Allergic rhinitis is associated with at least a four- to fivefold increased risk of developing asthma.
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Title Annotation:desloratadine
Author:Jancin, Bruce
Publication:Internal Medicine News
Geographic Code:4EUGE
Date:Jan 1, 2002
Words:273
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