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Antidepressants improve symptoms in fibromyalgia sufferers.

Fibromyalgia syndrome (FMS) is a chronic pain disorder associated with multiple debilitating symptoms and high disease-related costs. Researchers set out to determine the efficacy of antidepressants in the treatment of fibromyalgia by performing a meta-analysis of randomized controlled clinical trials. Their findings were published in the Jan. 14 issue of the Journal of the American Medical Association. Randomized placebo-controlled trials with tricyclic and tetracyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRIs), and monoamine oxidase inhibitors (MAOIs) were analyzed. Eighteen randomized controlled trials involving 1,427 participants were included. Overall, treatment with antidepressant medications was associated with improvements in pain, depression, fatigue, sleep disturbances, and health-related quality of life in patients with fibromyalgia.


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Title Annotation:NEWS BRIEFS
Publication:Healthy Years
Date:Mar 1, 2009
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